Clocapramine  (Synonyms: Clocarpramine; 3-Chlorocarpipramine)

Clocapramine is an antagonist of the D₂, 5-HT_2A receptors.

Clocapramine has a moderate affinity for D₂-receptors in vitro. Clocapramine shows higher affinity for 5-HT_2A than for D₂-receptors in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clocapramine shows the lowest potency for D₂-occupancy in vivo^[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D₂ and frontal serotonin-5-HT₂ receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT₂ versus D₂ receptors that fall between these two groups (ED₅₀ of 14.5 mg/kg for D₂, 4.9 mg/kg for 5-HT₂)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

481.07

C₂₈H₃₇ClN₄O

47739-98-0

O=C(C1(N2CCCCC2)CCN(CCCN3C4=CC(Cl)=CC=C4CCC5=CC=CC=C53)CC1)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69(4):399-412.  [Content Brief]

  [2]. Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64.  [Content Brief]