Dopamine Receptor

Dopamine Receptor Related Products (321):

By Type:	Pan (5) Selective (1)
By Effects:	Inhibitors (59) Agonists (78) Antagonists (133) Activators (3) Modulators (12) Chemical (1)

Cat. No.	Product Name	Effect	Purity

HY-15608

MPTP hydrochloride		99.54%
MPTP hydrochloride is a brain penetrant dopamine neurotoxin. MPTP hydrochloride can be used to induces Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP⁺, induces apoptosis. MPTP hydrochloride has been verified by MCE with professional biological experiments.

HY-14541

Olanzapine	Antagonist	99.83%
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic.

HY-135147

ONC206	Antagonist	99.90%
ONC206 is an analogue of TRAIL inducer ONC201. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.

HY-A0081

Fluphenazine dihydrochloride	Inhibitor	99.89%
Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.

HY-B1752A

Quinpirole hydrochloride	Agonist	99.97%
Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor.

HY-U00096

Ansofaxine hydrochloride	Inhibitor	99.72%
Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC₅₀ values of 723, 491 and 763 nM, respectively.

HY-118956

Adrogolide hydrochloride	Agonist
Adrogolide hydrochloride (ABT-431 hydrochloride) is a chemically stable prodrug that can convert to the dopamine D1 receptor agonist A-86929. Adrogolide hydrochloride ameliorates the MPTP (HY-15608)-induced Parkinson's Disease in marmoset model, reduces the dyskinesias tendency. Adrogolide hydrochloride reverses Risperidone (HY-11018)-induced cognitive deficits in monkey.

HY-B0735A

Fenoldopam mesylate	Agonist	99.94%
Fenoldopam mesylate (SKF-82526) is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis.

HY-B1371

Spiperone	Antagonist	99.00%
Spiperone is a potent dopamine D2, serotonin 5-HT_1A, and serotonin 5-HT_2A antagonist. Spiperone is a widely used pharmacological tool. Spiperone has the potential for the research of neurology diseases.

HY-N0300

Tetrahydropalmatine	Inhibitor	99.72%
Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

HY-N0925

Tetrahydroberberine	Antagonist	98.61%
Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach.

HY-110080

Lisuride maleate	Agonist	99.97%
Lisuride (maleate) is a potent agonist of dopamine with a probably direct action on dopaminergic receptors. Lisuride (maleate) is an ergot derivative. Lisuride (maleate) releases the premenstrual mastalgia without significant side effects.

HY-B1693

Levomepromazine	Antagonist	99.98%
Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors.

HY-B1110

Nomifensine	Inhibitor	98.93%
Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

HY-109157

Ralmitaront		99.92%
Ralmitaront (RO6889450) is an orally active agonist of trace amine-associated receptor 1 (TAAR1) with a EC₅₀ value of 110.4 nM. Ralmitaront has antipsychotic, cognitively improvement, and antidepressant activity in rodents. Ralmitaront can be used as a neurosuppressant in the study of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder.

HY-B1240

Droperidol	Antagonist	99.90%
Droperidol is a butyrophenone-type Dopamine-2 receptor antagonist.

HY-113468A

3-O-Methyldopa	Inhibitor	≥98.0%
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

HY-17355A

Dexpramipexole dihydrochloride	Agonist	99.94%
Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist.

HY-128770

LY3154207	Agonist	99.87%
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC₅₀=3 nM).

HY-B1110A

Nomifensine maleate	Inhibitor	98.79%
Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

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