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Clozic is a potential anti-arthritic agent.

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Clozic Chemical Structure

Clozic Chemical Structure

CAS No. : 22494-47-9

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Based on 1 publication(s) in Google Scholar

Clozic Related Antibodies

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Description

Clozic is a potential anti-arthritic agent.

In Vitro

Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clozic Related Antibodies
Molecular Weight

304.77

Formula

C17H17ClO3
CAS No.
SMILES

CC(C)(OCC1=CC=C(C2=CC=C(Cl)C=C2)C=C1)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Cell Assay
[1]

Approximately 3×104 to 5×104 cells/mL medium are seeded into 24-well plates and incubated at 37°C in a humidified atmosphere of 95% air/5% CO2. Medium is replaced with fresh medium containing 20% foetal calf serum and methanol or Clozic under investigation. Cell numbers are determined in replicate wells on various days during culture growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Clozic Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clozic22494-47-9ICI 55897 ClobuzaritICI55897ICI-55897OthersInhibitorinhibitorinhibit

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