D-Sedoheptulose 7-phosphate 

D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds ^[1].

Sedoheptulose 7-phosphate can be converted to ADP-l-glycero-β-d-manno-heptose by SepB, SepL, and SepC, it involves in ADP-sugar in microbial natural product biosynthesis^[1].
SepB is an S-7-P isomerase, SepL involves in the biosynthesis of heptoses of the core region of E. coli LPS, and they catalyze a four-reaction relay converting S-7-P into ADP-d-glycero-β-d-manno-heptose ^[1].
Septacidin and its analogs are potential anticancer and pain-relief agents^[1].
Hygromycin B is an anthelmintic agent practically used in swine and poultry farming^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

290.16

C₇H₁₅O₁₀P

2646-35-7

Solid

White to yellow

OCC([C@H]([C@@H]([C@@H]([C@@H](COP(O)(O)=O)O)O)O)O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Tang W, et al. d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B.Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2818-2823.  [Content Brief]