2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Dorzolamide

Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Dorzolamide hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Dorzolamide Chemical Structure

Dorzolamide Chemical Structure

CAS No. : 120279-96-1

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Dorzolamide Related Antibodies

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Description

Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1].
In Vitro

Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dorzolamide Related Antibodies
In Vivo

Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss albino mice (EAC solid tumor)[3].
Dosage: 3, 10, or 30 mg/kg/day (synergized mitomycin C).
Administration: IP, daily for 3 weeks.
Result: Upregulated TXNIP and p53 while downregulated bcl-2.
Effective in retarding the growth of EAC in mice.
Clinical Trial
Molecular Weight

324.44

Formula

C10H16N2O4S3
CAS No.
SMILES

O=S(C(S1)=CC2=C1S([C@@H](C)C[C@@H]2NCC)(=O)=O)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dorzolamide Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dorzolamide120279-96-1L671152 MK507L 671152L-671152MK507MK 507MK-507Carbonic AnhydraseCarbonate dehydrataseCA-IIanti-tumorEACsolidtumorInhibitorinhibitorinhibit

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