2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG2-N3

(S,R,S)-AHPC-PEG2-N3  (Synonyms: VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13)

Cat. No.: HY-103599 Purity: 99.74%
SDS COA Handling Instructions

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(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG2-N3 Chemical Structure

(S,R,S)-AHPC-PEG2-N3 Chemical Structure

CAS No. : 2010159-45-0

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5 mg USD 91 In-stock
10 mg USD 136 In-stock
50 mg USD 340 In-stock
100 mg USD 550 In-stock
500 mg USD 1950 In-stock
1 g USD 3350 In-stock
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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-PEG2-N3 Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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  • Purity & Documentation

  • References

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Description

(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target[1]

VHL

 

Molecular Weight

601.72

Formula

C28H39N7O6S
CAS No.
Appearance

Liquid

Color

Off-white to yellow

SMILES

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (207.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (83.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6619 mL 8.3095 mL 16.6190 mL
5 mM 0.3324 mL 1.6619 mL 3.3238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

SDS (252 KB)

COA (254 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.6619 mL 8.3095 mL 16.6190 mL 41.5476 mL
5 mM 0.3324 mL 1.6619 mL 3.3238 mL 8.3095 mL
10 mM 0.1662 mL 0.8310 mL 1.6619 mL 4.1548 mL
15 mM 0.1108 mL 0.5540 mL 1.1079 mL 2.7698 mL
20 mM 0.0831 mL 0.4155 mL 0.8310 mL 2.0774 mL
25 mM 0.0665 mL 0.3324 mL 0.6648 mL 1.6619 mL
30 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3849 mL
40 mM 0.0415 mL 0.2077 mL 0.4155 mL 1.0387 mL
50 mM 0.0332 mL 0.1662 mL 0.3324 mL 0.8310 mL
60 mM 0.0277 mL 0.1385 mL 0.2770 mL 0.6925 mL
80 mM 0.0208 mL 0.1039 mL 0.2077 mL 0.5193 mL
DMSO 100 mM 0.0166 mL 0.0831 mL 0.1662 mL 0.4155 mL
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(S,R,S)-AHPC-PEG2-N3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG2-N32010159-45-0VH032-PEG2-N3 VHL Ligand-Linker Conjugates 6 E3 ligase Ligand-Linker Conjugates 13E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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