2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG2-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride  (Synonyms: VH032-PEG2-NH2 hydrochloride; VHL Ligand-Linker Conjugates 3 hydrochloride; E3 ligase Ligand-Linker Conjugates 6)

Cat. No.: HY-103603 Purity: 99.77%
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(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG2-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-PEG2-NH2 hydrochloride Chemical Structure

CAS No. : 2097973-72-1

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5 mg USD 45 In-stock
10 mg USD 70 In-stock
25 mg USD 140 In-stock
50 mg USD 220 In-stock
100 mg USD 310 In-stock
500 mg USD 760 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-PEG2-NH2 hydrochloride:

(S,R,S)-AHPC-PEG2-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

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Description

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG2-NH2 hydrochloride Related Antibodies
Molecular Weight

612.18

Formula

C28H42ClN5O6S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (245.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (163.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6335 mL 8.1675 mL 16.3351 mL
5 mM 0.3267 mL 1.6335 mL 3.2670 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (81.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.77%

SDS (393 KB)

COA (254 KB) HNMR (133 KB) LCMS (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.6335 mL 8.1675 mL 16.3351 mL 40.8377 mL
5 mM 0.3267 mL 1.6335 mL 3.2670 mL 8.1675 mL
10 mM 0.1634 mL 0.8168 mL 1.6335 mL 4.0838 mL
15 mM 0.1089 mL 0.5445 mL 1.0890 mL 2.7225 mL
20 mM 0.0817 mL 0.4084 mL 0.8168 mL 2.0419 mL
25 mM 0.0653 mL 0.3267 mL 0.6534 mL 1.6335 mL
30 mM 0.0545 mL 0.2723 mL 0.5445 mL 1.3613 mL
40 mM 0.0408 mL 0.2042 mL 0.4084 mL 1.0209 mL
50 mM 0.0327 mL 0.1634 mL 0.3267 mL 0.8168 mL
60 mM 0.0272 mL 0.1361 mL 0.2723 mL 0.6806 mL
80 mM 0.0204 mL 0.1021 mL 0.2042 mL 0.5105 mL
100 mM 0.0163 mL 0.0817 mL 0.1634 mL 0.4084 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S,R,S)-AHPC-PEG2-NH2 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG2-NH22097973-72-1VH032-PEG2-NH2VHL Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 6E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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