2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG4-NH2

(S,R,S)-AHPC-PEG4-NH2  (Synonyms: VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base)

Cat. No.: HY-103604A Purity: 98.39%
SDS COA Handling Instructions

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(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG4-NH2 Chemical Structure

(S,R,S)-AHPC-PEG4-NH2 Chemical Structure

CAS No. : 2010159-57-4

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Based on 2 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-PEG4-NH2:

(S,R,S)-AHPC-PEG4-NH2 Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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  • Purity & Documentation

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Description

(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

VHL

 

In Vitro

E3 ligase Ligand-Linker Conjugates 7 Free Base, extracted from patent US20170008904A1, can be used in the synthesis of compound A1895 in example 3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG4-NH2 Related Antibodies
Molecular Weight

663.83

Formula

C32H49N5O8S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 170 mg/mL (256.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5064 mL 7.5320 mL 15.0641 mL
5 mM 0.3013 mL 1.5064 mL 3.0128 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.51%

SDS (394 KB)

COA (248 KB) LCMS (110 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5064 mL 7.5320 mL 15.0641 mL 37.6602 mL
5 mM 0.3013 mL 1.5064 mL 3.0128 mL 7.5320 mL
10 mM 0.1506 mL 0.7532 mL 1.5064 mL 3.7660 mL
15 mM 0.1004 mL 0.5021 mL 1.0043 mL 2.5107 mL
20 mM 0.0753 mL 0.3766 mL 0.7532 mL 1.8830 mL
25 mM 0.0603 mL 0.3013 mL 0.6026 mL 1.5064 mL
30 mM 0.0502 mL 0.2511 mL 0.5021 mL 1.2553 mL
40 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9415 mL
50 mM 0.0301 mL 0.1506 mL 0.3013 mL 0.7532 mL
60 mM 0.0251 mL 0.1255 mL 0.2511 mL 0.6277 mL
80 mM 0.0188 mL 0.0942 mL 0.1883 mL 0.4708 mL
100 mM 0.0151 mL 0.0753 mL 0.1506 mL 0.3766 mL
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(S,R,S)-AHPC-PEG4-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG4-NH22010159-57-4VH032-PEG4-NH2 VHL Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 7E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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