2. Anti-infection
  3. Bacterial Antibiotic
  4. Fosfomycin calcium

Fosfomycin calcium  (Synonyms: MK-​0955 calcium)

Cat. No.: HY-B1075 Purity: ≥98.0%
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Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

For research use only. We do not sell to patients.

Fosfomycin calcium Chemical Structure

Fosfomycin calcium Chemical Structure

CAS No. : 26016-98-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
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10 mM * 1 mL in Water USD 66 In-stock
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Based on 6 publication(s) in Google Scholar

Other Forms of Fosfomycin calcium:

Fosfomycin calcium Related Antibodies

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Description

Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].

In Vitro

Fosfomycin calcium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis[1].
Fosfomycin calcium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%[1].
Fosfomycin calcium displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fosfomycin calcium Related Antibodies
In Vivo

Fosfomycin calcium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes[3].
Pharmacokinetic of Fosfomycin calcium in Rats[4]

Dibekacin Dose (mg) Vdss (l/kg) β (min-1) T1/2 (min) Urinary recovery (%)
30 0.261 0.0244 28.4 85

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats[3]
Dosage: 320 mg/kg
Administration: Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result: Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.
Animal Model: Dehydrated Wistar rat with acute renal failure (8-week-old)[4]
Dosage: 120 mg/kg
Administration: Intravenous injection; once
Result: Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.
Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.
Clinical Trial
Molecular Weight

176.12

Formula

C3H5CaO4P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@@H](P([O-])([O-])=O)O1.[Ca+2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (283.90 mM; ultrasonic and adjust pH to 2 with HCl)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6779 mL 28.3897 mL 56.7795 mL
5 mM 1.1356 mL 5.6779 mL 11.3559 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (253 KB) HNMR (155 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6779 mL 28.3897 mL 56.7795 mL 141.9487 mL
5 mM 1.1356 mL 5.6779 mL 11.3559 mL 28.3897 mL
10 mM 0.5678 mL 2.8390 mL 5.6779 mL 14.1949 mL
15 mM 0.3785 mL 1.8926 mL 3.7853 mL 9.4632 mL
20 mM 0.2839 mL 1.4195 mL 2.8390 mL 7.0974 mL
25 mM 0.2271 mL 1.1356 mL 2.2712 mL 5.6779 mL
30 mM 0.1893 mL 0.9463 mL 1.8926 mL 4.7316 mL
40 mM 0.1419 mL 0.7097 mL 1.4195 mL 3.5487 mL
50 mM 0.1136 mL 0.5678 mL 1.1356 mL 2.8390 mL
60 mM 0.0946 mL 0.4732 mL 0.9463 mL 2.3658 mL
80 mM 0.0710 mL 0.3549 mL 0.7097 mL 1.7744 mL
100 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4195 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fosfomycin calcium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosfomycin26016-98-8MK-​0955BacterialAntibioticsepsispharmacokineticsafetymultidrug-resistantMDRextensively drug-resistantXDRpan-drug-resistantPDR,antimicrobial activityantibioticdibekacinnephrotoxicitydrug eliminationrenal lysosomedehydrated mouseInhibitorinhibitorinhibit

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