2. Anti-infection
  3. Bacterial Antibiotic
  4. Fosfomycin tromethamine

Fosfomycin tromethamine  (Synonyms: MK-0955 tromethamine)

Cat. No.: HY-B0609 Purity: 99.69%
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Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

For research use only. We do not sell to patients.

Fosfomycin tromethamine Chemical Structure

Fosfomycin tromethamine Chemical Structure

CAS No. : 78964-85-9

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50 mg USD 130 In-stock
100 mg USD 195 In-stock
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Based on 6 publication(s) in Google Scholar

Other Forms of Fosfomycin tromethamine:

Fosfomycin tromethamine Related Antibodies

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Description

Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].

In Vitro

Fosfomycin tromethamine is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis[1].
Fosfomycin tromethamine has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%[1].
Fosfomycin tromethamine displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fosfomycin tromethamine Related Antibodies
In Vivo

Fosfomycin tromethamine (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes in rats[3].
Pharmacokinetic of Fosfomycin Tromethamine in Rats[4]

Dibekacin Dose (mg) Vdss (l/kg) β (min-1) T1/2 (min) Urinary recovery (%)
30 0.261 0.0244 28.4 85

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats[3]
Dosage: 320 mg/kg
Administration: Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result: Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.
Animal Model: Dehydrated Wistar rat with acute renal failure (8-week-old)[4]
Dosage: 120 mg/kg
Administration: Intravenous injection; once
Result: Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.
Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.
Clinical Trial
Molecular Weight

259.19

Formula

C7H18NO7P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]1O[C@@H]1P(O)(O)=O.OCC(CO)(N)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (964.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8582 mL 19.2909 mL 38.5817 mL
5 mM 0.7716 mL 3.8582 mL 7.7163 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.8582 mL 19.2909 mL 38.5817 mL 96.4543 mL
5 mM 0.7716 mL 3.8582 mL 7.7163 mL 19.2909 mL
10 mM 0.3858 mL 1.9291 mL 3.8582 mL 9.6454 mL
15 mM 0.2572 mL 1.2861 mL 2.5721 mL 6.4303 mL
20 mM 0.1929 mL 0.9645 mL 1.9291 mL 4.8227 mL
25 mM 0.1543 mL 0.7716 mL 1.5433 mL 3.8582 mL
30 mM 0.1286 mL 0.6430 mL 1.2861 mL 3.2151 mL
40 mM 0.0965 mL 0.4823 mL 0.9645 mL 2.4114 mL
50 mM 0.0772 mL 0.3858 mL 0.7716 mL 1.9291 mL
60 mM 0.0643 mL 0.3215 mL 0.6430 mL 1.6076 mL
80 mM 0.0482 mL 0.2411 mL 0.4823 mL 1.2057 mL
100 mM 0.0386 mL 0.1929 mL 0.3858 mL 0.9645 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fosfomycin tromethamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosfomycin78964-85-9MK-0955MK0955MK 0955BacterialAntibioticsepsispharmacokineticsafetymultidrug-resistantMDRextensively drug-resistantXDRpan-drug-resistantPDR,antimicrobial activityantibioticdibekacinnephrotoxicitydrug eliminationrenal lysosomedehydrated mouseInhibitorinhibitorinhibit

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