2. Anti-infection
  3. Bacterial Antibiotic
  4. Fosmidomycin sodium salt

Fosmidomycin sodium salt  (Synonyms: FR-31564)

Cat. No.: HY-112853 Purity: 99.32%
SDS COA Handling Instructions

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Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

For research use only. We do not sell to patients.

Fosmidomycin sodium salt Chemical Structure

Fosmidomycin sodium salt Chemical Structure

CAS No. : 66508-37-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 534 In-stock
Solution
10 mM * 1 mL in Water USD 534 In-stock
Solid
5 mg USD 485 In-stock
10 mg USD 820 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fosmidomycin sodium salt:

Fosmidomycin sodium salt Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fosmidomycin sodium salt

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

Cellular Effect
Cell Line Type Value Description References
MRC5 IC50
> 64 μM
Compound: 1
Cytotoxicity against human MRC5 cells after 24 hrs by resazurin assay
Cytotoxicity against human MRC5 cells after 24 hrs by resazurin assay
[PMID: 30344904]
MRC5 CC50
> 64 μM
Compound: 1
Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
[PMID: 30879839]
In Vitro

Fosmidomycin sodium salt is a phosphonic acid antibiotic[1][2], which is active against both Gram-negative and Gram-positive bacteria[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fosmidomycin sodium salt Related Antibodies
In Vivo

Animals treated intraperitoneally with dosages of >10 mg/kg of fosmidomycin are apparently free of parasites. After treatment with 5 mg/kg of fosmidomycin, parasitemias are <1%. Animals treated orally with 50 or 100 mg/kg of fosmidomycin are apparently free of parasites, and parasitemias are <1% after treatment with 20 mg/kg of drug. Recrudescence is observed when the treatment is terminated after 4 days. Mice treated with 30 mg/kg of fosmidomycin over a period of 8 days are totally cured[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

205.08

Formula

C4H9NNaO5P
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

OP(CCCN(C=O)O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (121.90 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8761 mL 24.3807 mL 48.7615 mL
5 mM 0.9752 mL 4.8761 mL 9.7523 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (487.61 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.32%

SDS (252 KB)

COA (246 KB) HNMR (480 KB) LCMS (94 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8761 mL 24.3807 mL 48.7615 mL 121.9036 mL
5 mM 0.9752 mL 4.8761 mL 9.7523 mL 24.3807 mL
10 mM 0.4876 mL 2.4381 mL 4.8761 mL 12.1904 mL
15 mM 0.3251 mL 1.6254 mL 3.2508 mL 8.1269 mL
20 mM 0.2438 mL 1.2190 mL 2.4381 mL 6.0952 mL
25 mM 0.1950 mL 0.9752 mL 1.9505 mL 4.8761 mL
30 mM 0.1625 mL 0.8127 mL 1.6254 mL 4.0635 mL
40 mM 0.1219 mL 0.6095 mL 1.2190 mL 3.0476 mL
50 mM 0.0975 mL 0.4876 mL 0.9752 mL 2.4381 mL
60 mM 0.0813 mL 0.4063 mL 0.8127 mL 2.0317 mL
80 mM 0.0610 mL 0.3048 mL 0.6095 mL 1.5238 mL
100 mM 0.0488 mL 0.2438 mL 0.4876 mL 1.2190 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fosmidomycin sodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosmidomycin66508-37-0FR-31564FR31564FR 31564BacterialAntibioticInhibitorinhibitorinhibit

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