2. Cytoskeleton
  3. Integrin
  4. GRGDSP

GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

GRGDSP Chemical Structure

GRGDSP Chemical Structure

CAS No. : 91037-75-1

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1 mg USD 50 In-stock
5 mg USD 130 In-stock
10 mg USD 198 In-stock
25 mg USD 360 In-stock
50 mg USD 500 In-stock
100 mg USD 700 In-stock
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of GRGDSP:

GRGDSP Related Antibodies

Top Publications Citing Use of Products

    GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022; 12(17): 7307-7318

    Immunofluorescence staining images of NeuN and ITGB1 in the peri-infarct area. GRGDSP significantly downregulates rOPN-induced ITGB1.

    GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022; 12(17): 7307-7318

    GRGDSP decreases the expression of ITGB1 in the peri-infarct area.

    GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022; 12(17): 7307-7318

    GRGDSP (1 mg/kg; inject at the injured area; single daily for 15 days) apparently reduces the densities of Mpz+, Ki67+and Sox10+ schwann cells in the injured area in the Dhhcre/+;Ninj2fl/fl mice.

    View All Integrin Isoform Specific Products:

    View All Isoforms
    αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.

    IC50 & Target

    Integrin[1]
    In Vitro

    It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis[1]. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    GRGDSP Related Antibodies
    Molecular Weight

    587.58

    Formula

    C22H37N9O10
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Gly-Arg-Gly-Asp-Ser-Pro
    Sequence Shortening

    GRGDSP
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (170.19 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7019 mL 8.5095 mL 17.0190 mL
    5 mM 0.3404 mL 1.7019 mL 3.4038 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.91%

    COA (249 KB) RP-HPLC (258 KB) MS (79 KB) Elemental Analysis Report (108 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.7019 mL 8.5095 mL 17.0190 mL 42.5474 mL
    5 mM 0.3404 mL 1.7019 mL 3.4038 mL 8.5095 mL
    10 mM 0.1702 mL 0.8509 mL 1.7019 mL 4.2547 mL
    15 mM 0.1135 mL 0.5673 mL 1.1346 mL 2.8365 mL
    20 mM 0.0851 mL 0.4255 mL 0.8509 mL 2.1274 mL
    25 mM 0.0681 mL 0.3404 mL 0.6808 mL 1.7019 mL
    30 mM 0.0567 mL 0.2836 mL 0.5673 mL 1.4182 mL
    40 mM 0.0425 mL 0.2127 mL 0.4255 mL 1.0637 mL
    50 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8509 mL
    60 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7091 mL
    80 mM 0.0213 mL 0.1064 mL 0.2127 mL 0.5318 mL
    100 mM 0.0170 mL 0.0851 mL 0.1702 mL 0.4255 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    GRGDSP Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GRGDSP91037-75-1IntegrinInhibitorinhibitorinhibit

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