GSK376501A

Cat. No.: HY-101746 Purity: 99.06%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

For research use only. We do not sell to patients.

GSK376501A Chemical Structure

CAS No. : 1010412-80-2

Size	Price	Stock
1 mg	USD 413	Ask For Quote & Lead Time
5 mg	USD 950	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
Customer Review

Description

GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus^[1].

IC₅₀ & Target^[1]

PPARγ

Molecular Weight

531.64

Formula

C₃₂H₃₇NO₆

CAS No.

1010412-80-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N1CC2=CC(OCCOC)=CC(OCCOC)=C2)=C(C3=CC=C(C(C)(C)C)C=C3)C4=C1C=CC=C4)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (188.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8810 mL	9.4049 mL	18.8097 mL
5 mM	0.3762 mL	1.8810 mL	3.7619 mL
10 mM	0.1881 mL	0.9405 mL	1.8810 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.06%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (252 KB) HNMR (216 KB) RP-HPLC (125 KB)

Handling Instructions (2659 KB)

References

[1]. Kae M. Bullock, et al. Process Development and Scale-Up of a PPARγ Agonist: Selection of the Manufacture Route. Org. Process Res. Dev. 2009, 13, 2, 303-309.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8810 mL	9.4049 mL	18.8097 mL	47.0243 mL
	5 mM	0.3762 mL	1.8810 mL	3.7619 mL	9.4049 mL
	10 mM	0.1881 mL	0.9405 mL	1.8810 mL	4.7024 mL
	15 mM	0.1254 mL	0.6270 mL	1.2540 mL	3.1350 mL
	20 mM	0.0940 mL	0.4702 mL	0.9405 mL	2.3512 mL
	25 mM	0.0752 mL	0.3762 mL	0.7524 mL	1.8810 mL
	30 mM	0.0627 mL	0.3135 mL	0.6270 mL	1.5675 mL
	40 mM	0.0470 mL	0.2351 mL	0.4702 mL	1.1756 mL
	50 mM	0.0376 mL	0.1881 mL	0.3762 mL	0.9405 mL
	60 mM	0.0313 mL	0.1567 mL	0.3135 mL	0.7837 mL
	80 mM	0.0235 mL	0.1176 mL	0.2351 mL	0.5878 mL
	100 mM	0.0188 mL	0.0940 mL	0.1881 mL	0.4702 mL

GSK376501A Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK376501A1010412-80-2PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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