2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. GSK376501A

GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

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GSK376501A Chemical Structure

GSK376501A Chemical Structure

CAS No. : 1010412-80-2

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5 mg USD 950 Ask For Quote & Lead Time

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GSK376501A Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus[1].

IC50 & Target[1]

PPARγ

 

Molecular Weight

531.64

Formula

C32H37NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N1CC2=CC(OCCOC)=CC(OCCOC)=C2)=C(C3=CC=C(C(C)(C)C)C=C3)C4=C1C=CC=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (188.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8810 mL 9.4049 mL 18.8097 mL
5 mM 0.3762 mL 1.8810 mL 3.7619 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8810 mL 9.4049 mL 18.8097 mL 47.0243 mL
5 mM 0.3762 mL 1.8810 mL 3.7619 mL 9.4049 mL
10 mM 0.1881 mL 0.9405 mL 1.8810 mL 4.7024 mL
15 mM 0.1254 mL 0.6270 mL 1.2540 mL 3.1350 mL
20 mM 0.0940 mL 0.4702 mL 0.9405 mL 2.3512 mL
25 mM 0.0752 mL 0.3762 mL 0.7524 mL 1.8810 mL
30 mM 0.0627 mL 0.3135 mL 0.6270 mL 1.5675 mL
40 mM 0.0470 mL 0.2351 mL 0.4702 mL 1.1756 mL
50 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.9405 mL
60 mM 0.0313 mL 0.1567 mL 0.3135 mL 0.7837 mL
80 mM 0.0235 mL 0.1176 mL 0.2351 mL 0.5878 mL
100 mM 0.0188 mL 0.0940 mL 0.1881 mL 0.4702 mL
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GSK376501A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK376501A1010412-80-2PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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