2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. GV-196771A

GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.

For research use only. We do not sell to patients.

GV-196771A Chemical Structure

GV-196771A Chemical Structure

CAS No. : 166974-23-8

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Description

GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.

IC50 & Target

NMDA Receptor

 

In Vivo

GV196771 is a potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate receptor. GV196771 is a potent antagonist of the modulatory glycine site of the NMDA receptor developed for treatment of neuropathic pain. GV196771 is an NMDA receptor antagonist with low oral bioavailability in rats and mice. GV196771 has low oral bioavailability (<10%) and plasma clearance (~2 mL/min/kg) in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

423.22

Formula

C20H13Cl2N2NaO3
CAS No.
SMILES

O=C(C(N1)=C(/C=C2C(N(C3=CC=CC=C3)CC/2)=O)C4=C1C=C(Cl)C=C4Cl)[O-].[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[1]

Mice[1]
Male wild-type FVB mdr1a/1b+/+ and Pgp-deficient knockout FVBmdr1a/1b-/- mice (20-30 g) are used. Dose solutions of 0.2 mg/mL for GV196771 and 5.0 mg/mL for GF120918 are prepared fresh using 0.5% hydroxypropylmethylcellulose and 1% Tween 80 as a vehicle. Two hours before the administration of GV196771, the animals are divided into two groups. One group receive a single oral dose (10 mL/kg) of vehicle and the second group receive a single 50 mg/kg oral dose (10 mL/kg) of GF120918. Two hours later, all animals receive a single 2 mg/kg oral dose (10 mL/kg) of GV196771. At scheduled time points, mice are anesthetized with CO2 and blood samples are obtained by cardiac puncture. Blood is centrifuged to yield plasma. The MDR genotype of each animal is confirmed by a polymerase chain reaction assay after study completion.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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GV-196771A Related Classifications

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Keywords:

GV-196771A166974-23-8iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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