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RGH-5526 (GYKI-11679) is a new antihypertensive agent.

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RGH-5526 Chemical Structure

RGH-5526 Chemical Structure

CAS No. : 69579-13-1

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RGH-5526 Related Antibodies

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Description

RGH-5526 (GYKI-11679) is a new antihypertensive agent.

In Vivo

RGH-5526 (GYKI-11679) is a new antihypertensive agent. Results show a sharp (61%) reduction in the hypothalamic Noradrenaline (NA) level 2 h after the administration of 10 mg/kg of RGH-5526, and this effect lasts for 4 to 6 h. It is demonstrated that RGH-5526 exerts a greater NA lowering effect in the hypothalamus than in the periphery. RGH-5526 does not influence the hypothalamic monoamine oxidase (MAO)-activity following prolonged treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

335.40

Formula

C16H25N5O3
CAS No.
SMILES

C/C(CC(OC(C)(C)C)=O)=N\NC1=NN=C(N2CCOCC2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[1]

Rats are used and treated with GYKI-11679 (0.5 mL of 1% Tween 80 suspension) at various dosages. They are killed at the specified times by decapitation; the heart is immediately removed, cut open, and rinsed in an isotonic saline solution. The brain is placed on ice and the hypothalamus is dissected. The tissues are weighed, homogenized in 5% trichloroacetic acid (TCA) containing 0.2% EDTA and ascorbic acid, and centrifuged for 1 h at 5000×g. The supernatant is processed on alumina and noradrenaline in the eluate is determined spectrofluorimetrically[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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RGH-5526 Related Classifications

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Keywords:

RGH-552669579-13-1GYKI-11679RGH5526RGH 5526GYKI11679GYKI 11679OthersInhibitorinhibitorinhibit

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