2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Gidazepam

Gidazepam  (Synonyms: Gidasepam; Hidazepam; Hydazepam)

Cat. No.: HY-U00315 Purity: 98.03%
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Gidazepam is an agonist of GABA receptor channels (GABA RCs).

For research use only. We do not sell to patients.

Gidazepam Chemical Structure

Gidazepam Chemical Structure

CAS No. : 129186-29-4

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Other Forms of Gidazepam:

Gidazepam Related Antibodies

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Description

Gidazepam is an agonist of GABA receptor channels (GABA RCs).

IC50 & Target

GABA receptor[1]
In Vitro

Gidazepam demonstrates considerably lower affinities to GABA RCs than phenazepam, 3-hydrozyphenazepam, and Br-nordiazepam. This is manifested in different values of the inhibition constant (Ki) of binding of a specific ligand of benzodiazepine receptors, diazepam. For Gidazepam, the Ki value is 2,200±50 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gidazepam Related Antibodies
In Vivo

Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam (GDZ, 1 mg/kg); ester 1 (175 mg/kg); ester 2 (20 mg/kg); esters 3 and 4 (200 mg/kg); mixtures of Gidazepam and esters 1-4. All esters of GABA with monoterpenes display antiseizure effects in 3 h after oral administration as evidenced by increasing of inducing clonic-tonic convulsions (DCTC) and tonic extension (DTE) values. Gidazepam (1 mg/kg) is found to protect against seizures with DCTC and DTE values of 250% and 215%, accordingly; whereas co-administration of Gidazepam and esters 5-7 is shown to increase anticonvulsant activity compared with each compound alone[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

387.23

Formula

C17H15BrN4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NN)CN1C(CN=C(C2=CC=CC=C2)C3=CC(Br)=CC=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (645.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5824 mL 12.9122 mL 25.8244 mL
5 mM 0.5165 mL 2.5824 mL 5.1649 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[1]

Mice[1]
The outbreed male white mice (18-22 g) are used. Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam 1 mg/kg (GDZ); GABA ester of menthol 175 mg/kg (1); GABA ester of thymol 20 mg/kg (2); GABA ester of carvacrol 200 mg/kg (3); GABA ester of guaiacol 200 mg/kg (4); mixture of Gidazepam and 1; mixture of Gidazepam and 2; mixture of Gidazepam and 3; mixture of Gidazepam and 4. Doses of esters 1-4 are calculated in equimolar amounts with respect to monoterpenes based on our preliminary investigation and from literature citations. The anticonvulsant activity of compounds 1-4 and Gidazepam as well as mixtures of Gidazepam with 1-4 is evaluated in model of acute generalized seizures; pharmacological effect of compounds is estimated in 3 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5824 mL 12.9122 mL 25.8244 mL 64.5611 mL
5 mM 0.5165 mL 2.5824 mL 5.1649 mL 12.9122 mL
10 mM 0.2582 mL 1.2912 mL 2.5824 mL 6.4561 mL
15 mM 0.1722 mL 0.8608 mL 1.7216 mL 4.3041 mL
20 mM 0.1291 mL 0.6456 mL 1.2912 mL 3.2281 mL
25 mM 0.1033 mL 0.5165 mL 1.0330 mL 2.5824 mL
30 mM 0.0861 mL 0.4304 mL 0.8608 mL 2.1520 mL
40 mM 0.0646 mL 0.3228 mL 0.6456 mL 1.6140 mL
50 mM 0.0516 mL 0.2582 mL 0.5165 mL 1.2912 mL
60 mM 0.0430 mL 0.2152 mL 0.4304 mL 1.0760 mL
80 mM 0.0323 mL 0.1614 mL 0.3228 mL 0.8070 mL
100 mM 0.0258 mL 0.1291 mL 0.2582 mL 0.6456 mL
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Gidazepam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gidazepam129186-29-4Gidasepam Hidazepam HydazepamGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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