Gluten Exorphin C

Name: Gluten Exorphin C
Brand: MedChemExpress
SKU: HY-P1596
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1596 Purity: 98.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC₅₀ values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Gluten Exorphin C Chemical Structure

CAS No. : 142479-62-7

Size	Price	Stock	Quantity
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

δ Opioid Receptor/DOR

μ Opioid Receptor/MOR

In Vitro

Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC₅₀s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

591.70

Formula

C₂₉H₄₅N₅O₈

CAS No.

142479-62-7

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Pro-Ile-Ser-Leu

Sequence Shortening

YPISL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (169.00 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6900 mL	8.4502 mL	16.9005 mL
5 mM	0.3380 mL	1.6900 mL	3.3801 mL
10 mM	0.1690 mL	0.8450 mL	1.6900 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (84.50 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.97%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (256 KB) LCMS (91 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)

References

[1]. Fukudome S, et al. Gluten exorphin C. A novel opioid peptide derived from wheat gluten. FEBS Lett. 1993 Jan 18;316(1):17-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.6900 mL	8.4502 mL	16.9005 mL	42.2511 mL
	5 mM	0.3380 mL	1.6900 mL	3.3801 mL	8.4502 mL
	10 mM	0.1690 mL	0.8450 mL	1.6900 mL	4.2251 mL
	15 mM	0.1127 mL	0.5633 mL	1.1267 mL	2.8167 mL
	20 mM	0.0845 mL	0.4225 mL	0.8450 mL	2.1126 mL
	25 mM	0.0676 mL	0.3380 mL	0.6760 mL	1.6900 mL
	30 mM	0.0563 mL	0.2817 mL	0.5633 mL	1.4084 mL
	40 mM	0.0423 mL	0.2113 mL	0.4225 mL	1.0563 mL
	50 mM	0.0338 mL	0.1690 mL	0.3380 mL	0.8450 mL
	60 mM	0.0282 mL	0.1408 mL	0.2817 mL	0.7042 mL
	80 mM	0.0211 mL	0.1056 mL	0.2113 mL	0.5281 mL
	100 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.4225 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.