2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Hemokinin 1 (mouse)

Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

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Hemokinin 1 (mouse) Chemical Structure

Hemokinin 1 (mouse) Chemical Structure

CAS No. : 208041-90-1

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Based on 1 publication(s) in Google Scholar

Hemokinin 1 (mouse) Related Antibodies

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Description

Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

IC50 & Target

Ki: 0.175 nM (Human NK1 receptor), 560 nM (Human NK2 receptor)[1]
In Vitro

Hemokinin 1 (mouse) (1 nM-3 μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80 mM). Hemokinin 1 (mouse) (10 nM-10 μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hemokinin 1 (mouse) Related Antibodies
In Vivo

Hemokinin 1 (mouse) (0.01-100 nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10 nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2 nmol/kg (0.1-0.4 nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1 nmol/kg (0.07-0.2 nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100 nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1413.65

Formula

C61H100N22O15S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

RSRTRQFYGLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (70.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7074 mL 3.5369 mL 7.0739 mL
5 mM 0.1415 mL 0.7074 mL 1.4148 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[1]

Male albino Wistar Rats weighing 400-450 g are used throughout the study. On the day of the experiment, rats are anaesthetized with urethane (1.2 g/kg, s.c.). Following tracheotomy and placement of a tracheal cannula (PE 205), the left jugular vein is cannulated (PE50) for SP or Hemokinin 1 (mouse) administrations. The body temperature is maintained constant (36.5±0.5°C) by a thermoregulated heating lamp. About 1 h elapsed between the animal set-up and the start of the experiments, thereafter each animal receive atropine (1.4 μmol/kg i.v. as bolus followed by infusion of 1.4 μM in a volume of 300 μL/h) and 10 min later the vehicle (saline) and increasing doses (0.5 log units) of SP or Hemokinin 1 (mouse) (0.01, 0.03, 0.1, 0.3, 1, 3, 10, 30, and 100 nmol/kg); the first five doses are administered at 20 min intervals, whereas 30 min elapsed between each of the last four doses. Atropine pretreatment is performed in order to minimize the influence of cholinergic secretory reflexes in response to the placement of the cotton swab in the rat's oral cavity for the measurement of salivary secretion induced by SP or Hemokinin 1 (mouse).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7074 mL 3.5369 mL 7.0739 mL 17.6847 mL
5 mM 0.1415 mL 0.7074 mL 1.4148 mL 3.5369 mL
10 mM 0.0707 mL 0.3537 mL 0.7074 mL 1.7685 mL
15 mM 0.0472 mL 0.2358 mL 0.4716 mL 1.1790 mL
20 mM 0.0354 mL 0.1768 mL 0.3537 mL 0.8842 mL
25 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7074 mL
30 mM 0.0236 mL 0.1179 mL 0.2358 mL 0.5895 mL
40 mM 0.0177 mL 0.0884 mL 0.1768 mL 0.4421 mL
50 mM 0.0141 mL 0.0707 mL 0.1415 mL 0.3537 mL
60 mM 0.0118 mL 0.0589 mL 0.1179 mL 0.2947 mL
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Hemokinin 1 (mouse) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hemokinin 1 (mouse)208041-90-1Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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