ICA (Synonyms: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)

Name: ICA
Brand: MedChemExpress
SKU: HY-22044
Rating: 4.5 (1 reviews)

Cat. No.: HY-22044 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

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ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC₅₀ of 2.1 µM.

For research use only. We do not sell to patients.

ICA Chemical Structure

CAS No. : 3374-88-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 504	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 504	In-stock	Estimated Time of Arrival: December 31
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5 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC₅₀ of 2.1 µM.

IC₅₀ & Target

IC50: 2.1 µM (Antileishmanial)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.025 μM Compound: 1	Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assay Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assay	[PMID: 18774291]
HEK293	IC₅₀	0.043 μM Compound: 1	Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay	[PMID: 18774291]
HEK293	IC₅₀	0.123 μM Compound: 1	Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay	[PMID: 18774291]
HEK293	IC₅₀	0.29 μM Compound: 1	Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay	[PMID: 18774291]
HEK293	IC₅₀	0.543 μM Compound: 1	Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay	[PMID: 18774291]
J774.A1	IC₅₀	2.1 μM Compound: 25	Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 expressing luciferase reporter gene infected in mouse J-774A1 cells assessed as inhibition of amastigote stage formation incubated for 72 hrs by luminometry Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 expressing luciferase reporter gene infected in mouse J-774A1 cells assessed as inhibition of amastigote stage formation incubated for 72 hrs by luminometry	[PMID: 26318065]
KB	CC₅₀	75.6 μM Compound: 25	Cytotoxicity in human KB cells assessed as cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human KB cells assessed as cell viability incubated for 72 hrs by MTT assay	[PMID: 26318065]

In Vitro

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

254.31

Formula

C₁₃H₁₀N₄S

CAS No.

3374-88-7

Appearance

Solid

Color

Light brown to brown

SMILES

C1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 49.5 mg/mL (194.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9322 mL	19.6610 mL	39.3221 mL
5 mM	0.7864 mL	3.9322 mL	7.8644 mL
10 mM	0.3932 mL	1.9661 mL	3.9322 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

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Data Sheet (274 KB) SDS (252 KB)

COA (251 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. [Content Brief]

[2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9322 mL	19.6610 mL	39.3221 mL	98.3052 mL
	5 mM	0.7864 mL	3.9322 mL	7.8644 mL	19.6610 mL
	10 mM	0.3932 mL	1.9661 mL	3.9322 mL	9.8305 mL
	15 mM	0.2621 mL	1.3107 mL	2.6215 mL	6.5537 mL
	20 mM	0.1966 mL	0.9831 mL	1.9661 mL	4.9153 mL
	25 mM	0.1573 mL	0.7864 mL	1.5729 mL	3.9322 mL
	30 mM	0.1311 mL	0.6554 mL	1.3107 mL	3.2768 mL
	40 mM	0.0983 mL	0.4915 mL	0.9831 mL	2.4576 mL
	50 mM	0.0786 mL	0.3932 mL	0.7864 mL	1.9661 mL
	60 mM	0.0655 mL	0.3277 mL	0.6554 mL	1.6384 mL
	80 mM	0.0492 mL	0.2458 mL	0.4915 mL	1.2288 mL
	100 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.9831 mL

ICA Related Classifications

Infection Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICA3374-88-7N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamineParasiteInhibitorinhibitorinhibit

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ICA (Synonyms: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)

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Complete Stock Solution Preparation Table

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