2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK2 JH2 Tracer

JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM.

For research use only. We do not sell to patients.

JAK2 JH2 Tracer Chemical Structure

JAK2 JH2 Tracer Chemical Structure

CAS No. : 2101955-00-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 495 In-stock
Solution
10 mM * 1 mL in DMSO USD 495 In-stock
Solid
1 mg USD 150 In-stock
5 mg USD 450 In-stock
10 mg USD 750 In-stock
50 mg USD 2500 In-stock
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Based on 4 publication(s) in Google Scholar

JAK2 JH2 Tracer Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2].

In Vitro

JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM[1].
JAK2 JH2 Tracer shows a dissociation constants near 0.2 μM[1].
JAK2 JH2 Tracer shows a high binding affinity with a Kd value of 0.2 μM for JAK2 JH2 domain by saturation experiments[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JAK2 JH2 Tracer Related Antibodies
In Vivo

The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2].
Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

747.73

Formula

C38H27F2N7O6S
CAS No.
Appearance

Solid

Color

Light brown to brown

Emission (Em)

515
Excitation (Ex)

488
SMILES

S=C(NC1=CC2=C(C3(C4=C(OC5=C3C=CC(O)=C5)C=C(O)C=C4)OC2=O)C=C1)N(CC6=CC=C(NC7=NN(C(C8=C(F)C=CC=C8F)=O)C(N)=N7)C=C6)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (111.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3374 mL 6.6869 mL 13.3738 mL
5 mM 0.2675 mL 1.3374 mL 2.6748 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3374 mL 6.6869 mL 13.3738 mL 33.4345 mL
5 mM 0.2675 mL 1.3374 mL 2.6748 mL 6.6869 mL
10 mM 0.1337 mL 0.6687 mL 1.3374 mL 3.3435 mL
15 mM 0.0892 mL 0.4458 mL 0.8916 mL 2.2290 mL
20 mM 0.0669 mL 0.3343 mL 0.6687 mL 1.6717 mL
25 mM 0.0535 mL 0.2675 mL 0.5350 mL 1.3374 mL
30 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1145 mL
40 mM 0.0334 mL 0.1672 mL 0.3343 mL 0.8359 mL
50 mM 0.0267 mL 0.1337 mL 0.2675 mL 0.6687 mL
60 mM 0.0223 mL 0.1114 mL 0.2229 mL 0.5572 mL
80 mM 0.0167 mL 0.0836 mL 0.1672 mL 0.4179 mL
100 mM 0.0134 mL 0.0669 mL 0.1337 mL 0.3343 mL
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JAK2 JH2 Tracer Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK2 JH2 Tracer2101955-00-2JAKJanus kinaseJNJ7706621NVP-BSK805filgotinibGLPG0634Inhibitorinhibitorinhibit

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