2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. K-Ras G12C-IN-2

K-Ras G12C-IN-2 is an irreversible covalent K-Ras G12C inhibitor.

For research use only. We do not sell to patients.

K-Ras G12C-IN-2 Chemical Structure

K-Ras G12C-IN-2 Chemical Structure

CAS No. : 1629267-75-9

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K-Ras G12C-IN-2 Related Antibodies

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Description

K-Ras G12C-IN-2 is an irreversible covalent K-Ras G12C inhibitor.

IC50 & Target[1]

KRas G12C

 

In Vitro

K-Ras G12C-IN-2 is a covalent kras g12c inhibitor extracted from patent WO2014152588A1, compound V-35[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K-Ras G12C-IN-2 Related Antibodies
Molecular Weight

418.92

Formula

C21H27ClN4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(C2CC2)C=C(NCC(N3CCN(C4CN(C(C=C)=O)C4)CC3)=O)C(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 22 mg/mL (52.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3871 mL 11.9355 mL 23.8709 mL
5 mM 0.4774 mL 2.3871 mL 4.7742 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.21%

COA (246 KB) HNMR (213 KB) LCMS (428 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3871 mL 11.9355 mL 23.8709 mL 59.6773 mL
5 mM 0.4774 mL 2.3871 mL 4.7742 mL 11.9355 mL
10 mM 0.2387 mL 1.1935 mL 2.3871 mL 5.9677 mL
15 mM 0.1591 mL 0.7957 mL 1.5914 mL 3.9785 mL
20 mM 0.1194 mL 0.5968 mL 1.1935 mL 2.9839 mL
25 mM 0.0955 mL 0.4774 mL 0.9548 mL 2.3871 mL
30 mM 0.0796 mL 0.3978 mL 0.7957 mL 1.9892 mL
40 mM 0.0597 mL 0.2984 mL 0.5968 mL 1.4919 mL
50 mM 0.0477 mL 0.2387 mL 0.4774 mL 1.1935 mL
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K-Ras G12C-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras G12C-IN-21629267-75-9RasInhibitorinhibitorinhibit

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