2. Anti-infection
  3. Dengue virus Flavivirus HCV
  4. KIN1408

KIN1408 is an agonist of the RIG-1-like receptor (RLR) pathway and exhibits a broad-spectrum antiviral activity. KIN1408 exhibits activity against HCV, influenza A, dengue virus 2, Ebola, Nipah, and Lassa viruses.

For research use only. We do not sell to patients.

KIN1408 Chemical Structure

KIN1408 Chemical Structure

CAS No. : 1903800-11-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 110 In-stock
Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 340 In-stock
50 mg USD 540 In-stock
100 mg USD 860 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

KIN1408 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE KIN1408

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KIN1408 is an agonist of the RIG-1-like receptor (RLR) pathway and exhibits a broad-spectrum antiviral activity. KIN1408 exhibits activity against HCV, influenza A, dengue virus 2, Ebola, Nipah, and Lassa viruses[1][2].

In Vitro

KIN1408 has the potency to drive IRF3 activation to induce innate immune gene (MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells) expression and that concomitantly suppress dengue virus2 RNA to levels. KIN1408 also exhibits activity against HCV, influenza A, Ebola, Nipah, and Lassa viruses[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIN1408 Related Antibodies
Molecular Weight

479.50

Formula

C25H19F2N3O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C(SC(NC(C2=CC=C(OC(F)F)C=C2)C3=C(O)C(N=CC=C4)=C4C=C3)=N5)C5=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 39 mg/mL (81.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0855 mL 10.4275 mL 20.8551 mL
5 mM 0.4171 mL 2.0855 mL 4.1710 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0855 mL 10.4275 mL 20.8551 mL 52.1376 mL
5 mM 0.4171 mL 2.0855 mL 4.1710 mL 10.4275 mL
10 mM 0.2086 mL 1.0428 mL 2.0855 mL 5.2138 mL
15 mM 0.1390 mL 0.6952 mL 1.3903 mL 3.4758 mL
20 mM 0.1043 mL 0.5214 mL 1.0428 mL 2.6069 mL
25 mM 0.0834 mL 0.4171 mL 0.8342 mL 2.0855 mL
30 mM 0.0695 mL 0.3476 mL 0.6952 mL 1.7379 mL
40 mM 0.0521 mL 0.2607 mL 0.5214 mL 1.3034 mL
50 mM 0.0417 mL 0.2086 mL 0.4171 mL 1.0428 mL
60 mM 0.0348 mL 0.1738 mL 0.3476 mL 0.8690 mL
80 mM 0.0261 mL 0.1303 mL 0.2607 mL 0.6517 mL
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KIN1408 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIN14081903800-11-2KIN 1408KIN-1408Dengue virusFlavivirusHCVDENVHepatitis C virusInhibitorinhibitorinhibit

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