2. GPCR/G Protein Anti-infection
  3. Prostaglandin Receptor SARS-CoV
  4. KW-8232 free base

KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

For research use only. We do not sell to patients.

KW-8232 free base Chemical Structure

KW-8232 free base Chemical Structure

CAS No. : 170365-25-0

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Based on 1 publication(s) in Google Scholar

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Description

KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].

IC50 & Target

EP

 

Cellular Effect
Cell Line Type Value Description References
Vero C1008 EC50
1.2 μM
Compound: KW 8232
Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs
Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs
[PMID: 32511357]
In Vitro

KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].
KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KW-8232 free base Related Antibodies
In Vivo

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male Sprague-Dawley rats (5-week-old)[1].
Dosage: 1, 3, 10, and 30 mg/kg.
Administration: Orally once daily beginning 1 day prior to neurectomy for 28 days.
Result: Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.
Molecular Weight

609.16

Formula

C36H37ClN4O3
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(C(N1CCN(C)C)=C(C(C2=CC=C(O)C=C2)C3=CC=C(O)C=C3)C4=C1C=CC=C4)N5CCN(C6=CC=CC=C6Cl)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (261 KB)

Handling Instructions (2659 KB)
References
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KW-8232 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KW-8232170365-25-0KW8232KW 8232Prostaglandin ReceptorSARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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KW-8232 free base
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