L-689502

Cat. No.: HY-U00261: FAQs
Data Sheet Handling Instructions

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L-689502 is a potent inhibitor of HIV-l protease with an IC₅₀ of 1 nM.

For research use only. We do not sell to patients.

L-689502 Chemical Structure

CAS No. : 138483-63-3

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Description	L-689502 is a potent inhibitor of HIV-l protease with an IC₅₀ of 1 nM.
IC₅₀ & Target	IC50: 1 nM (HIV-l protease)^[1]
In Vitro	Both L694746 and L-689502 inhibit HIV-l ptotease activity in a concentration-dependent manner. Pepstatin is much less potent than either compound exhibiting an IC₅₀ of 2 μM. L694746 is as potent as L-689502 in inhibiting the HIV-l protease despite being structurally different from L-689502^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. L-689502 Related Antibodies
Molecular Weight	673.84
Formula	C₃₉H₅₁N₃O₇
CAS No.	138483-63-3
SMILES	O=C(OC(C)(C)C)N[C@@H](CC1=CC=CC=C1)[C@@H](O)C[C@@H](CC2=CC=C(OCCN3CCOCC3)C=C2)C(N[C@@H]4[C@H](O)CC5=C4C=CC=C5)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Lingham RB, et al. HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1456-61. [Content Brief]

Cell Assay
^[1]

G689502 (3.3 pmoles in 1 mL of 100% DMSO) is added to cultures that have been growing for 48 hr. The final substrate and DMSO concentrations during the fermentation period are 65 pM and 2%, respectively. The fermentations containing L-689502 are carried out for an additional 72-96 hr prior to be harvested.The whole broth is sequenthdly extracted with methanol (0.5 vol) and acetone (0.5 vol). The supematant containing the derivatives of L-689502 is separated from the mycelia by filtration^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Lingham RB, et al. HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1456-61. [Content Brief]

L-689502 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-689502138483-63-3L689502L 689502HIV ProteaseInhibitorinhibitorinhibit

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