2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase Phospholipase
  4. LY 178002

LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

For research use only. We do not sell to patients.

LY 178002 Chemical Structure

LY 178002 Chemical Structure

CAS No. : 107889-32-7

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LY 178002 Related Antibodies

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Description

LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

IC50 & Target[1]

5-LPO

0.6 μM (IC50)

PLA2

6.3 μM (IC50)

FCO

4.2 μM (IC50)

Cyclooxygenase

 

In Vitro

LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC50s of 0.1, 6.3 and 4.2 μM [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY 178002 Related Antibodies
In Vivo

LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

319.46

Formula

C18H25NO2S
CAS No.
SMILES

O=C1NCS/C1=C/C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY 178002 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY 178002107889-32-7LY178002LY-178002COXLipoxygenasePhospholipaseCyclooxygenaseLOXInhibitorinhibitorinhibit

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