Leucokinin VIII (Synonyms: Leucokinin 8)

Cat. No.: HY-P1496: FAQs
Data Sheet Handling Instructions

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Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.

For research use only. We do not sell to patients.

Leucokinin VIII Chemical Structure

CAS No. : 2703746-05-6

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Description

Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.

In Vitro

Leucokinin VIII is an octapeptide, increases the rates of transepithelial NaC1, KC1 and water secretion, increases the Cl conductance of the epithelial shunt via a receptor located at the basolateral side of the epithelium^[1]. Leucokinin VIII also activates Ca²⁺-dependent signal pathway in principal cells of Aedes aegyptiMalpighian tubules^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

872.92

Formula

C₄₂H₅₂N₁₀O₁₁

CAS No.

2703746-05-6

Sequence

Gly-Ala-Ser-Phe-Tyr-Ser-Trp-Gly-NH2

Sequence Shortening

GASFYSWG-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pannabecker TL, et al. Regulation of epithelial shunt conductance by the peptide leucokinin. J Membr Biol. 1993 Feb;132(1):63-76. [Content Brief]

[2]. Yu MJ, et al. Leucokinin activates Ca(2+)-dependent signal pathway in principal cells of Aedes aegypti Malpighian tubules. Am J Physiol Renal Physiol. 2002 Sep;283(3):F499-508. [Content Brief]

Leucokinin VIII Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leucokinin VIII2703746-05-6Leucokinin 8Leucokinin8Leucokinin-8OthersInhibitorinhibitorinhibit

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