2. Metabolic Enzyme/Protease
  3. 11β-HSD
  4. MK-0736

MK-0736 (Compounds 1) is highly potent and selective inhibitor of 11β-HSD1. MK-0736 can be used for the research of type 2 diabetes, hypertension and metabolic syndrome.

For research use only. We do not sell to patients.

MK-0736 Chemical Structure

MK-0736 Chemical Structure

CAS No. : 719272-79-4

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MK-0736 Related Antibodies

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Description

MK-0736 (Compounds 1) is highly potent and selective inhibitor of 11β-HSD1. MK-0736 can be used for the research of type 2 diabetes, hypertension and metabolic syndrome[1].

Cellular Effect
Cell Line Type Value Description References
CHO-K1 IC50
> 4000 nM
Compound: 32
Inhibition of mouse 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay
Inhibition of mouse 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay
[PMID: 21421311]
CHO-K1 IC50
> 4000 nM
Compound: 32
Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay
Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay
[PMID: 21421311]
CHO-K1 IC50
2.4 nM
Compound: 32
Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay
Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay
[PMID: 21421311]
CHO-K1 IC50
3.2 nM
Compound: 32
Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay
Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assay
[PMID: 21421311]
Molecular Weight

469.56

Formula

C23H30F3N3O2S
CAS No.
SMILES

FC(C1=CC=CC=C1C2=NN=C(C3(CC4)CCC4(CCCS(=O)(CC)=O)CC3)N2C)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MK-0736 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-0736719272-79-4MK0736MK 073611β-HSD11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenase11β-HSD1type 2 diabeteshypertensionmetabolic syndromeInhibitorinhibitorinhibit

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