2. JAK/STAT Signaling Stem Cell/Wnt Anti-infection
  3. STAT Antibiotic Parasite
  4. Niclosamide monohydrate

Niclosamide monohydrate  (Synonyms: BAY2353 monohydrate)

Cat. No.: HY-B0497B
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Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.

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Niclosamide monohydrate Chemical Structure

Niclosamide monohydrate Chemical Structure

CAS No. : 73360-56-2

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Niclosamide monohydrate Related Antibodies

Top Publications Citing Use of Products

    Niclosamide monohydrate purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC) significantly suppresses the colony formation ability, and reduces the numbers, as well as diameters, of colonies formed in AN3CA, Hec1B, and Ishikawa cells.

    Niclosamide monohydrate purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 0-8 μM; 24, 48, 72 h) significantly inhibits the metabolic viability of AN3CA, Hec1B, and Ishikawa cells both in a dose-dependent and a time-dependent manner, with the half maximal inhibitory concentration of < 1 μM at 72 h.

    Niclosamide monohydrate purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 1 μM) reduces number of cells that invaded across the trans-well chamber in Hec1B and Ishikawa endometrial cancer cell lines, suggesting NIC-mediated inhibition of invasive property of endometrial cancer cells.

    Niclosamide monohydrate purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 5 μM; 24 h) significantly reduces cyclin D1 and vimentin protein expression in human endometrial cancer cells.

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    Description

    Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].

    IC50 & Target[1]

    STAT3

    0.25 μM (IC50, in HeLa cells)

    In Vitro

    Niclosamide monohydrate (0.6 nM-46 μM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells[3].
    Niclosamide monohydrate (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells [4].
    Niclosamide monohydrate (10 μM) treatment inhibits virus replication in Vero E6 cells[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Niclosamide monohydrate Related Antibodies

    Cell Viability Assay[3]

    Cell Line: BD140A, SW-13 and NCI-H295R cells
    Concentration: 0.6 nM-46 µM
    Incubation Time:
    Result: Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 µM, 0.15 µM, and 0.53 µM in BD140A, SW-13, and NCI-H295R, respectively.

    Cell Viability Assay[4]

    Cell Line: Hela cells
    Concentration: 0.05-5 μM
    Incubation Time: 24 hours
    Result: Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.

    Cell Viability Assay[5]

    Cell Line: Vero E6 cells
    Concentration: 10 μM
    Incubation Time: 2 days
    Result: Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.
    In Vivo

    Niclosamide monohydrate (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nu+/Nu+ mice injected with NCI-H295R cells[3]
    Dosage: 100 mg/kg, 200 mg/kg
    Administration: Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
    Result: Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
    Clinical Trial
    Molecular Weight

    345.13

    Formula

    C13H10Cl2N2O5
    CAS No.
    SMILES

    O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Niclosamide monohydrate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Niclosamide73360-56-2BAY2353BAY 2353BAY-2353STATAntibioticParasiteBD140ASW-13NCI-H295RHelaVero E6antihelminthicbayluscideInhibitorinhibitorinhibit

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