Osteogenic Growth Peptide, OGP

Name: Osteogenic Growth Peptide, OGP
Brand: MedChemExpress
SKU: HY-P1563
Rating: 5.0 (2 reviews)

Cat. No.: HY-P1563 Purity: 98.35%: FAQs
Data Sheet SDS COA Handling Instructions

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Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Osteogenic Growth Peptide, OGP Chemical Structure

CAS No. : 132996-61-3

Size	Price	Stock	Quantity
5 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 630	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE Osteogenic Growth Peptide, OGP

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.

In Vitro

Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways^[1]. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH₂-ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1523.74

Formula

C₆₈H₁₁₀N₂₂O₁₈

CAS No.

132996-61-3

Appearance

Solid

Color

White to off-white

Sequence

Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly

Sequence Shortening

ALKRQGRTLYGFGG

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (65.63 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6563 mL	3.2814 mL	6.5628 mL
5 mM	0.1313 mL	0.6563 mL	1.3126 mL
10 mM	0.0656 mL	0.3281 mL	0.6563 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.35%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (247 KB) RP-HPLC (206 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Moore NM, et al. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via clickchemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials. 2010 Mar;31(7):1604-11. [Content Brief]

[2]. Pigossi SC, et al. Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1885. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.6563 mL	3.2814 mL	6.5628 mL	16.4070 mL
	5 mM	0.1313 mL	0.6563 mL	1.3126 mL	3.2814 mL
	10 mM	0.0656 mL	0.3281 mL	0.6563 mL	1.6407 mL
	15 mM	0.0438 mL	0.2188 mL	0.4375 mL	1.0938 mL
	20 mM	0.0328 mL	0.1641 mL	0.3281 mL	0.8203 mL
	25 mM	0.0263 mL	0.1313 mL	0.2625 mL	0.6563 mL
	30 mM	0.0219 mL	0.1094 mL	0.2188 mL	0.5469 mL
	40 mM	0.0164 mL	0.0820 mL	0.1641 mL	0.4102 mL
	50 mM	0.0131 mL	0.0656 mL	0.1313 mL	0.3281 mL
	60 mM	0.0109 mL	0.0547 mL	0.1094 mL	0.2734 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.