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  4. PK14105

PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.

For research use only. We do not sell to patients.

PK14105 Chemical Structure

PK14105 Chemical Structure

CAS No. : 107257-28-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 150 In-stock
25 mg USD 300 In-stock
50 mg USD 480 In-stock
100 mg USD 770 In-stock
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Based on 1 publication(s) in Google Scholar

PK14105 Related Antibodies

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Description

PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors. in vivo binding experiments, in which PK 14105 was injected into rats with unilaterally lesioned striata, demonstrate that PK 14105 rapidly crosses the blood-brain-barrier and that there is a marked retention of radioactivity in the lesioned striatum not seen in the unlesioned striatum or cerebellar vermis[1]. It can also inhibit receptor ligands, calcium channel ligands and co-transporter in all salivary glands[2].

Molecular Weight

381.40

Formula

C21H20FN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC2=C(C(C3=CC([N+]([O-])=O)=CC=C3F)=N1)C=CC=C2)N(C)C(C)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (78.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6219 mL 13.1096 mL 26.2192 mL
5 mM 0.5244 mL 2.6219 mL 5.2438 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6219 mL 13.1096 mL 26.2192 mL 65.5480 mL
5 mM 0.5244 mL 2.6219 mL 5.2438 mL 13.1096 mL
10 mM 0.2622 mL 1.3110 mL 2.6219 mL 6.5548 mL
15 mM 0.1748 mL 0.8740 mL 1.7479 mL 4.3699 mL
20 mM 0.1311 mL 0.6555 mL 1.3110 mL 3.2774 mL
25 mM 0.1049 mL 0.5244 mL 1.0488 mL 2.6219 mL
30 mM 0.0874 mL 0.4370 mL 0.8740 mL 2.1849 mL
40 mM 0.0655 mL 0.3277 mL 0.6555 mL 1.6387 mL
50 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.3110 mL
60 mM 0.0437 mL 0.2185 mL 0.4370 mL 1.0925 mL
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PK14105 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PK14105107257-28-3PK 14105PK-14105OthersInhibitorinhibitorinhibit

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