2. PROTAC
  3. PROTAC Linkers
  4. Cl-C6-PEG4-O-CH2COOH

Cl-C6-PEG4-O-CH2COOH  (Synonyms: PROTAC Linker 4)

Cat. No.: HY-112496 Purity: ≥98.0%
COA Handling Instructions

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Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).

For research use only. We do not sell to patients.

Cl-C6-PEG4-O-CH2COOH Chemical Structure

Cl-C6-PEG4-O-CH2COOH Chemical Structure

CAS No. : 1799506-30-1

Size Price Stock Quantity
25 mg USD 81 In-stock
50 mg USD 129 In-stock
100 mg USD 206 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Cl-C6-PEG4-O-CH2COOH Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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  • Purity & Documentation

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Description

Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs)[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cl-C6-PEG4-O-CH2COOH Related Antibodies
Molecular Weight

370.87

Formula

C16H31ClO7
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

ClCCCCCCOCCOCCOCCOCCOCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (269.64 mM; Need ultrasonic)

DMSO : 100 mg/mL (269.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6964 mL 13.4818 mL 26.9636 mL
5 mM 0.5393 mL 2.6964 mL 5.3927 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (239 KB) HNMR (200 KB) LCMS (322 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.6964 mL 13.4818 mL 26.9636 mL 67.4091 mL
5 mM 0.5393 mL 2.6964 mL 5.3927 mL 13.4818 mL
10 mM 0.2696 mL 1.3482 mL 2.6964 mL 6.7409 mL
15 mM 0.1798 mL 0.8988 mL 1.7976 mL 4.4939 mL
20 mM 0.1348 mL 0.6741 mL 1.3482 mL 3.3705 mL
25 mM 0.1079 mL 0.5393 mL 1.0785 mL 2.6964 mL
30 mM 0.0899 mL 0.4494 mL 0.8988 mL 2.2470 mL
40 mM 0.0674 mL 0.3370 mL 0.6741 mL 1.6852 mL
50 mM 0.0539 mL 0.2696 mL 0.5393 mL 1.3482 mL
60 mM 0.0449 mL 0.2247 mL 0.4494 mL 1.1235 mL
80 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8426 mL
100 mM 0.0270 mL 0.1348 mL 0.2696 mL 0.6741 mL
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Cl-C6-PEG4-O-CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cl-C6-PEG4-O-CH2COOH1799506-30-1PROTAC Linker 4PROTAC Linker4PROTAC Linker-4PROTAC LinkersInhibitorinhibitorinhibit

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