Peptide Modifications

Peptide modifications can be harnessed to change physical and chemical properties through structure modifications, thus improving bioactivities of specific peptides. MedChemExpress (MCE) offers hundreds of peptide modifications to help our researchers advance their projects. The peptide modifications listed below might assist you to choose suitable modifications.

N-terminus Modifications

•Ac
•Allyl
•Cholesteryl-
•N-Propargylglycine-
•Fmoc
•Acryl
•Fructose-
•Ad
•CBZ
•Alloc
•Glucose-
•BPS-
•Boc
•Pyr
•DMAP-Ac
•Morpholine-4-carbonyl-
•Bz
•D-Pyr
•NTriAc
•Trans-Cinnamoyl
•Bz (5-NH₂,2-NO₂)
•LA-
•PhAc
•2-Furoyl
•Bz (4-F)
•Mpa-
•Py-Ac
•Methacryl-
•Bz (4-NO₂)
•Tos
•N-Amidinoglycine
•BPA-

Fatty Acid

•For
•MeOSuc
•5-Hexynoic acid
•F-Lau-
•MeOCO
•Iba
•Heptanedioic acid
•Myr-
•2-Br-Ac
•pentenoic acid
•Oct-
•F-Myr-
•2-Cl-Ac
•pentinoyl
•F-Oct-
•Pentadeconyl-
•2-I-Ac
•Hex-
•Dec-
•Pal-
•OH-Ac
•5-heptenoic acid
•Sebacic acid
•Cys (Pal)
•3-Bromopropionyl
•Trans-3-hexenoyl-
•F-Dec-
•Pam3C-
•But-
•Linoletic-
•Undecyl-
•Ste-
•Suc
•10,12-Pentacosadiynoic acid
•Lau-
•Octanedioic acid

C-terminus Modifications

•-pNA
•-OMe
•-ONP
•-OSu
•-NH₂
•-OEt
•-AMC
•-NHMe
•-ol
•-OBzl
•-AFC
•-NHEt

D-Amino Acid

•D-Ala
•D-Lys
•D-Glu
•D-Tyr
•D-Arg
•D-Met
•D-Gln
•D-Thr
•D-Asp
•D-Pro
•D-His
•D-Trp
•D-Asn
•D-Phe
•D-Leu
•D-Val
•D-Cys
•D-Ser

Fluorescence / Dye Labeling

•Biotin-
•FITC-
•Dansyl-
•Lys (Dnp)
•DeThioBiotin
•-ED-FITC
•-EDDansyl
•D-Lys (Dnp)
•-EDBiotin
•-Lys (FITC)-
•-Lys (Dansyl)-
•Dab (Dnp)
•Glu (Biotin-PEG2)
•-Lys (FITC)
•-Lys (Dansyl)
•Dap (Dnp)
•-Lys (Biotin)-
•Lys (Ahx-FITC)
•Dansli-e-Lys
•-EDDnp
•-Lys (Biotin)
•FITC-e-Lys
•Dansyl-Ahx-
•-Lys (LC-Biotin)-
•FITC-Ahx-
•5-FAM-
•-Lys (LC-Biotin)
•5-TAMRA-
•5,6-FAM
•Biotin-e-Lys
•5 (6)-TAMTA-
•6’FAM
•Lys (S-S-Biotin)
•-EDYAMRA
•-ED-5-FAM
•Biotin-Ahx-
•-Lys (TAMRA)-
•-Lys (5-FAM)-
•Orn (Bio)
•-Lys (5-TAMRA)
•Lys (5,6-FAM)
•MCA-
•5-TAMRA-e-Lys
•-Lys (5-FAM)
•-Lys (MCA)-
•5-TAMRA-Acp
•5-FAM-E-Lys
•-Lys (MCA)
•5-FAM-Ahx-
•Lys (MCA)-

Phe and Tyr Modified Derivative

•D-2-Cl-Phe
•D-4-F-Phe
•L-2-Me-Phe
•L-3-I-Tyr
•L-2-Cl-Phe
•L-4-F-Phe
•D-4-Me-Phe
•D-3,5-DiI-Tyr
•D-3-Cl-Phe
•D-4-NO₂-Phe
•L-4-Me-Phe
•L-3,5-DiI-Tyr
•L-3-Cl-Phe
•L-4-NO₂-Phe
•D-4-NH₂-Phe
•D-3-NO₂-Tyr
•D-4-Cl-Phe
•D-4-I-Phe
•L-4-NH₂-Phe
•L-3-NO₂-Tyr
•L-4-Cl-Phe
•L-4-I-Phe
•D-3-Cl-Tyr
•D-3,5-DiNO₂-Tyr
•D-3,4-DiCl-Phe
•D-3-CN-Phe
•L-3-Cl-Tyr
•L-3,5-DiNO₂-Tyr
•L-3,4-DiCl-Phe
•L-3-CN-Phe
•D-3,5-DiCl-Tyr
•L-3-F-Tyr
•D-4-Br-Phe
•D-4-CN-Phe
•L-3,5-DiCl-Tyr
•L-4-NO₂-Phg
•L-4-Br-Phe
•L-4-CN-Phe
•D-3,5-DiBr-Tyr
•D-4-NO₂-Phg
•D-3-F-Phe
•D-2-Me-Phe
•L-3,5-DiBr-Tyr
•L-3,5-DiF-Phe
•L-3-F-Phe
•D-3-I-Tyr

Homo Amino Acid

•Har
•HomoCit
•beta-HomoMet
•beta-HomoSer
•D-Har
•D-HomoCit
•beta-HomoPro
•beta-HomoThr
•Hcy
•HomoLeu
•beta-HomoVal
•beta-HomoTrp
•HPh
•HomoPro
•beta-HomoAsp
•beta-HomoTyr
•D-HPh
•D-HomoPro
•beta-HomoAsn
•Azidohomoalanine
•Hse
•beta-HomoIle
•beta-HomoGlu
•beta-HomoAla
•D-Hse
•beta-HomoLeu
•beta-HomoGln
•beta-HomoPhe

Branched Peptide

•Symmetric 2 Branches
•Symmetric 4 Branches
•Symmetric 8 Branches
•Lys symmetric 2 Branches
•Lys symmetric 4 Branches
•Lys symmetric 8 Branches
•Orn symmetric 2 Branches
•Orn symmetric 4 Branches
•Orn symmetric 8 Branches
•Glu 2 Branches (Pure)
•Glycerol 3 Branches ester
•Thr (Peptide2)
•Ser (Peptide2)
•Lys (Peptide2)

BSA, KLH, OVA Conjugation

•BSA-Peptide N terminus
•KLH-Peptide N terminus
•OVA-Peptide N terminus
•BSA-Peptide C terminus
•KLH-Peptide C terminus
•OVA-Peptide C terminus
•BSA-Peptide via Cys
•KLH-Peptide via Cys
•OVA-Peptide via Cys

Linker Modifications

•Gly
•Ava
•AEA
•GABA
•Beta-Ala
•Ahx
•Ado
•Mini-PEG
•Mini-PEG2
•Mini-PEG3
•PEG4

Methylation

•Lys (Me)
•Arg (Me)
•Tyr (Me)
•Tyr (Et)
•Lys (Me₂)
•Arg (Me₂)asymmetrical
•Thr (Me)
•D-Tyr (Et)
•Lys (Me₃)
•Arg (Me₂) symmetrical
•Ser (Me)

Cyclic Peptide

•Mono Disulfide bridge
•Double Disulfide bridge
•Triple Disulfide bridge
•Random Triple Disulfide bridge
•Same Sequence Inter-Disulfide bridge by Cys oxidation
•Different Sequence Inter-Disulfide bridge by Cys oxidation
•Oxidation between Se-Cys
•Amide Cyclic (end)
•Amide Cyclic (side chain) by Lys
•Amide Cyclic (side chain) by Orn

Phosphorylation

•pSer
•D-pSer
•Di-sites in sequence
•4-sites in sequence
•pTyr
•D-pTyr
•Tri-sites in sequence
•5-sites in sequence
•pThr
•D-pThr

Resin Peptide

•peptide on Wang Resin
•peptide on 2-CTC Resin
•peptide on Rink Amide AM Resin
•peptide on Rink Amide MBHA Resin

Special Amino Acid

•beta-Asp
•3-Thi
•D-Chg
•Cys (pMeBzl)
•D-beta-Asp
•Aib
•Ac6c
•Cys (pMeOBzl)
•gamma-Glu
•Abu
•Dab
•Oic
•D- gamma-Glu
•D-Abu
•Dap
•Tic
•Cys (Cam)
•Hyp
•Pra
•D-Tic
•D-Cys (Cam)
•Phg
•D-Pra
•Cys (Bzl)
•Cys (Acm)
•D-Phg
•Allo-Thr
•Epsilon-Lys
•Cys (tBu)
•Nva
•D-Allo-Thr
•D-Epsilon-Lys
•Cys (StBu)
•D-Nva
•Gly (allyl)
•5-ASA
•Met (O)
•Nle
•D-Gly (allyl)
•Bpa
•D-Met (O)
•D-Nle
•Cys (Pyrene-maleimide)
•Pip
•Cys (SNO)
•Cit
•D-1-Nal
•Nip
•Met (O)₂
•D-Cit
•L-1-Nal
•2-Aze
•D-Met (O)₂
•Orn
•D-2-Nal
•3-Aze
•Lys (Ac)
•D-Orn
•L-2-Nal
•[Psi (CH₂NH)]
•Ac-Lys
•Pen
•D-2-Pal
•[CS-NH]
•Lys (Dde)
•D-Pen
•L-2-Pal
•Se-Met
•Tle
•Cpg
•D-3-Pal
•Se-Cys
•Ser (Octanoic acid)
•Cha
•L-3-pal
•DOPA
•Ser (Lipoic acid)
•D-Cha
•D-4-Pal
•isoGln
•D-Ser (Octanoic acid)
•Chg
•L-4-Pal
•D-isoGln
•Arg (Boc₂)
•Asp-OMe
•D-Glu (OtBu)
•Lys (Z)
•Arg (NO₂)
•Asp-OtBu
•Gln (Trt)
•Ser (Bzl)
•Arg (Z₂)
•Asn (Trt)
•His (Boc)
•Ser (Trt)
•Arg (pbf)
•Cys (MMt)
•His (Trt)
•Ser (tBu)
•D-Arg (pdf)
•Cys (Trt)
•Tyr (propargyl)
•Tyr (tBu)
•Asp (Oall)
•D-Cys (Trt)
•Lys (Boc)
•Asp (OBn)
•Glu (Oall)
•Lys (DMT)
•D-Tyr (tBu)
•Asp (OBzl)
•Glu (OBzl)
•Lys (Fomc)
•Thr (tBu)
•Asp (OMe)
•Glu (OMe)
•Lys (Mtt)
•Trp (Boc)
•Asp (OtBu)
•Glu (OtBu)
•Lys (Trt)
•Trp (Farnesyl)

Note:

1. The above information is for reference only. The available modifications are subject to laboratory confirmation.

2. For peptide modifications not listed in the tables, please send email to: sales@MedChemExpress.com.

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