Prinoxodan (Synonyms: RGW2938)

Cat. No.: HY-U00208 Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions

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Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.

For research use only. We do not sell to patients.

Prinoxodan Chemical Structure

CAS No. : 111786-07-3

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5 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 990	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3190	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5100	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
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Description

Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.

IC₅₀ & Target

Phosphodiesterase^[1]

In Vitro

Prinoxodan (RG W-2938) is an orally effective positive inotropic/vasodilator agent. Prinoxodan is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, Prinoxodan 5 nmol-5 μmol increases contractility in a dose-related fashion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Prinoxodan (RG W-2938) is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vivo in anesthetized and conscious dogs. Prinoxodan 30-300 μg/kg administered intravenously (i.v.) to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of Prinoxodan 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of Prinoxodan 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. Prinoxodan effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

257.27

Formula

C₁₃H₁₃N₄O₂

CAS No.

111786-07-3

Appearance

Solid

Color

White to yellow

SMILES

O=C1NC2=C(C=C(C3=N[N]C(CC3)=O)C=C2)CN1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : < 1 mg/mL (insoluble)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.83%

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Data Sheet (271 KB) SDS (393 KB)

COA (247 KB) HNMR (222 KB) RP-HPLC (297 KB) LCMS (109 KB)

Handling Instructions (2659 KB)

References

[1]. Artigou JY, et al. [Evaluation of a new cardiotonic agent on human isolated atrium]. Ann Cardiol Angeiol (Paris). 1993 Feb;42(2):79-82. [Content Brief]

[2]. Barrett JA, et al. Pharmacology of RG W-2938: a cardiotonic agent with vasodilator activity. J Cardiovasc Pharmacol. 1990 Oct;16(4):537-45. [Content Brief]

Prinoxodan Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prinoxodan111786-07-3RGW2938RGW 2938RGW-2938Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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