Risedronic acid (Synonyms: Risedronate)

Name: Risedronic acid
Brand: MedChemExpress
SKU: HY-B0148
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0148 Purity: ≥98.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM).

For research use only. We do not sell to patients.

Risedronic acid Chemical Structure

CAS No. : 105462-24-6

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Risedronic acid:

1 Publications Citing Use of MCE Risedronic acid

•Respir Res. 2022 Dec 28;23(1):380. [Abstract]

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	16 μM Compound: Risedronate	Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR	[PMID: 20457823]
JJN-3	EC₅₀	10 μM Compound: 2	Antiproliferative activity against human JJN-3 after 72 hrs by MTT assay Antiproliferative activity against human JJN-3 after 72 hrs by MTT assay	[PMID: 22390415]
MCF7	IC₅₀	248 μM Compound: Risedronate	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 48 hrs by SRB assay	[PMID: 33132173]
MCF7	IC₅₀	35.7 μM Compound: 1	Antiproliferative activity against human MCF7 cell line by MTT assay Antiproliferative activity against human MCF7 cell line by MTT assay	[PMID: 16970405]
NCI-H460	IC₅₀	43.7 μM Compound: 1	Antiproliferative activity against human NCI-H460 cell line by MTT assay Antiproliferative activity against human NCI-H460 cell line by MTT assay	[PMID: 16970405]
RPMI-8226	EC₅₀	13 μM Compound: 2a	Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay	[PMID: 23998921]
SF-268	IC₅₀	23.3 μM Compound: 1	Antiproliferative activity against human SF-268 cell line by MTT assay Antiproliferative activity against human SF-268 cell line by MTT assay	[PMID: 16970405]
T-cell	IC₅₀	6.2 μM Compound: 8	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL	[PMID: 14711309]
T-cell	IC₅₀	6.9 μM Compound: 8	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release	[PMID: 14711309]
Vero	ED₅₀	55 μM Compound: Risedronate	Antiparasitic activity against Trypanosoma cruzi amastigotes infected in gamma-irradiated vero cells assessed as growth inhibition measured after 3 days by fluorescence assay Antiparasitic activity against Trypanosoma cruzi amastigotes infected in gamma-irradiated vero cells assessed as growth inhibition measured after 3 days by fluorescence assay	[PMID: 23318904]
Vero	ED₅₀	55 μM Compound: 5	Antimicrobial activity against Trypanosoma cruzi CL amastigotes infected in african green monkey Vero cells measured on day 3 by fluorescence assay Antimicrobial activity against Trypanosoma cruzi CL amastigotes infected in african green monkey Vero cells measured on day 3 by fluorescence assay	[PMID: 24300918]

In Vitro

Risedronic acid (0-10 μM; 14 days) suppresses the formation of mineralized nodules in human mesenchymal stem cells (hMSC12) and rat thymus-derived mesenchymal stem cells (ST1BIIb)^[1].
Risedronic acid (0-10 μM; 3 days) suppresses the mRNA expression of osteoblast marker gene osteocalcin (OC) in human mesenchymal stem cells (hMSC12)^[1].
Risedronic acid (100-1000 μM; 48 h) induces chromatin condensation and activates caspase-3 in human mesenchymal stem cells (hMSC12)^[1].
Risedronic acid (Risedronate) (15 μM; 36 h) inhibits isoprenoid biosynthesis in Plasmodium falciparum, as shown by the decreased intensities of bands corresponding to farnesol (FOH) and geranylgeraniol (GGOH)^[3].
Risedronic acid (15 μM; 36 h) interferes with protein isoprenylation in Plasmodium falciparum, reducing the intensities of farnesylated protein bands and increasing those of geranylgeranylated protein bands^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis¹

Cell Line:	Human mesenchymal stem cells (hMSC12)
Concentration:	100 μM, 300 μM, 500 μM, 1000 μM
Incubation Time:	48 h
Result:	Induced chromatin condensation and activated caspase-3.

In Vivo

Risedronic acid (Risedronate) (30 μg/kg; subcutaneous injection; once every other day; 3 weeks) prevents radiation-induced osteoporosis in female C57BL/6 mice irradiated with 2 Gy X-rays, inhibits trabecular bone loss and microstructural damage, and suppresses the increase in osteoclast number and serum TRAP5b^[2].
Risedronic acid (10-25 mg/kg; intraperitoneal injection; once a day; 7 days) inhibits parasitemia in BALB/c mice infected with Plasmodium berghei strain ANKA, but does not prolong the survival time of mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body²
Dosage:	30 μg/kg
Administration:	Subcutaneous injection, once every other day, for 3 weeks
Result:	Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b.

Animal Model:	Male BALB/c mice (3-4 weeks old) infected with Plasmodium berghei strain ANKA by intraperitoneal injection of 1×10⁶ blood-stage parasites³
Dosage:	10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg
Administration:	Intraperitoneal injection, once a day, for 7 days
Result:	Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment.

Clinical Trial

Molecular Weight

283.11

Formula

C₇H₁₁NO₇P₂

CAS No.

105462-24-6

Appearance

Solid

Color

White to off-white

SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CC1=CN=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

0.1 M NaOH : 11 mg/mL (38.85 mM; ultrasonic and adjust pH to 7 with NaOH)

H₂O : 0.67 mg/mL (2.37 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5322 mL	17.6610 mL	35.3220 mL
5 mM	0.7064 mL	3.5322 mL	7.0644 mL
10 mM	0.3532 mL	1.7661 mL	3.5322 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (286 KB) SDS (393 KB)

COA (259 KB) HNMR (262 KB)

Handling Instructions (2659 KB)

References

[1]. Fujita H, et al. Effect of risedronate on osteoblast differentiation, expression of receptor activator of NF-κB ligand and apoptosis in mesenchymal stem cells. Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):78-84. [Content Brief]

[2]. Willey JS, et al. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone. 2010 Jan;46(1):101-11. [Content Brief]

[3]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / 0.1 M NaOH	1 mM	3.5322 mL	17.6610 mL	35.3220 mL	88.3049 mL
0.1 M NaOH	5 mM	0.7064 mL	3.5322 mL	7.0644 mL	17.6610 mL
	10 mM	0.3532 mL	1.7661 mL	3.5322 mL	8.8305 mL
	15 mM	0.2355 mL	1.1774 mL	2.3548 mL	5.8870 mL
	20 mM	0.1766 mL	0.8830 mL	1.7661 mL	4.4152 mL
	25 mM	0.1413 mL	0.7064 mL	1.4129 mL	3.5322 mL
	30 mM	0.1177 mL	0.5887 mL	1.1774 mL	2.9435 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Risedronic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Risedronic acid105462-24-6RisedronateParasiteApoptosisparasitehMSC12Plasmodium bergheiInhibitorinhibitorinhibit

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Risedronic acid (Synonyms: Risedronate)

Customer Review

Other Forms of Risedronic acid:

Risedronic acid Related Antibodies

1 Publications Citing Use of MCE Risedronic acid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Risedronic acid Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Risedronic acid Related Classifications

Keywords:

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SAFETY DATA SHEET (SDS)

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