1. Anti-infection Apoptosis
  2. Parasite Apoptosis
  3. Risedronic acid

Risedronic acid  (Synonyms: Risedronate)

Cat. No.: HY-B0148 Purity: ≥98.0%
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Risedronic acid (Risedronate), a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid inhibits blood stages of Plasmodium falciparum (IC50 of 20.3 μM). Risedronic acid inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins.

For research use only. We do not sell to patients.

Risedronic acid Chemical Structure

Risedronic acid Chemical Structure

CAS No. : 105462-24-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Risedronic acid:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Risedronic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Risedronic acid (Risedronate), a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid inhibits blood stages of Plasmodium falciparum (IC50 of 20.3 μM). Risedronic acid inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins[1][2][3].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
16 μM
Compound: Risedronate
Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR
Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR
[PMID: 20457823]
JJN-3 EC50
10 μM
Compound: 2
Antiproliferative activity against human JJN-3 after 72 hrs by MTT assay
Antiproliferative activity against human JJN-3 after 72 hrs by MTT assay
[PMID: 22390415]
MCF7 IC50
248 μM
Compound: Risedronate
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 48 hrs by SRB assay
[PMID: 33132173]
MCF7 IC50
35.7 μM
Compound: 1
Antiproliferative activity against human MCF7 cell line by MTT assay
Antiproliferative activity against human MCF7 cell line by MTT assay
[PMID: 16970405]
NCI-H460 IC50
43.7 μM
Compound: 1
Antiproliferative activity against human NCI-H460 cell line by MTT assay
Antiproliferative activity against human NCI-H460 cell line by MTT assay
[PMID: 16970405]
RPMI-8226 EC50
13 μM
Compound: 2a
Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay
Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay
[PMID: 23998921]
SF-268 IC50
23.3 μM
Compound: 1
Antiproliferative activity against human SF-268 cell line by MTT assay
Antiproliferative activity against human SF-268 cell line by MTT assay
[PMID: 16970405]
T-cell IC50
6.2 μM
Compound: 8
Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL
Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL
[PMID: 14711309]
T-cell IC50
6.9 μM
Compound: 8
Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release
Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release
[PMID: 14711309]
Vero ED50
55 μM
Compound: Risedronate
Antiparasitic activity against Trypanosoma cruzi amastigotes infected in gamma-irradiated vero cells assessed as growth inhibition measured after 3 days by fluorescence assay
Antiparasitic activity against Trypanosoma cruzi amastigotes infected in gamma-irradiated vero cells assessed as growth inhibition measured after 3 days by fluorescence assay
[PMID: 23318904]
Vero ED50
55 μM
Compound: 5
Antimicrobial activity against Trypanosoma cruzi CL amastigotes infected in african green monkey Vero cells measured on day 3 by fluorescence assay
Antimicrobial activity against Trypanosoma cruzi CL amastigotes infected in african green monkey Vero cells measured on day 3 by fluorescence assay
[PMID: 24300918]
In Vitro

Risedronic acid (0-10 μM; 14 days) suppresses the formation of mineralized nodules in human mesenchymal stem cells (hMSC12) and rat thymus-derived mesenchymal stem cells (ST1BIIb)1.
Risedronic acid (0-10 μM; 3 days) suppresses the mRNA expression of osteoblast marker gene osteocalcin (OC) in human mesenchymal stem cells (hMSC12)1.
Risedronic acid (100-1000 μM; 48 h) induces chromatin condensation and activates caspase-3 in human mesenchymal stem cells (hMSC12)1.
Risedronic acid (Risedronate) (15 μM; 36 h) inhibits isoprenoid biosynthesis in Plasmodium falciparum, as shown by the decreased intensities of bands corresponding to farnesol (FOH) and geranylgeraniol (GGOH)3.
Risedronic acid (15 μM; 36 h) interferes with protein isoprenylation in Plasmodium falciparum, reducing the intensities of farnesylated protein bands and increasing those of geranylgeranylated protein bands3.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis1

Cell Line: Human mesenchymal stem cells (hMSC12)
Concentration: 100 μM, 300 μM, 500 μM, 1000 μM
Incubation Time: 48 h
Result: Induced chromatin condensation and activated caspase-3.
In Vivo

Risedronic acid (Risedronate) (30 μg/kg; subcutaneous injection; once every other day; 3 weeks) prevents radiation-induced osteoporosis in female C57BL/6 mice irradiated with 2 Gy X-rays, inhibits trabecular bone loss and microstructural damage, and suppresses the increase in osteoclast number and serum TRAP5b2.
Risedronic acid (10-25 mg/kg; intraperitoneal injection; once a day; 7 days) inhibits parasitemia in BALB/c mice infected with Plasmodium berghei strain ANKA, but does not prolong the survival time of mice3.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body2
Dosage: 30 μg/kg
Administration: Subcutaneous injection, once every other day, for 3 weeks
Result: Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b.
Animal Model: Male BALB/c mice (3-4 weeks old) infected with Plasmodium berghei strain ANKA by intraperitoneal injection of 1×106 blood-stage parasites3
Dosage: 10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg
Administration: Intraperitoneal injection, once a day, for 7 days
Result: Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment.
Clinical Trial
Molecular Weight

283.11

Formula

C7H11NO7P2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CC1=CN=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

0.1 M NaOH : 11 mg/mL (38.85 mM; ultrasonic and adjust pH to 7 with NaOH)

H2O : 0.67 mg/mL (2.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5322 mL 17.6610 mL 35.3220 mL
5 mM 0.7064 mL 3.5322 mL 7.0644 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M NaOH 1 mM 3.5322 mL 17.6610 mL 35.3220 mL 88.3049 mL
0.1 M NaOH 5 mM 0.7064 mL 3.5322 mL 7.0644 mL 17.6610 mL
10 mM 0.3532 mL 1.7661 mL 3.5322 mL 8.8305 mL
15 mM 0.2355 mL 1.1774 mL 2.3548 mL 5.8870 mL
20 mM 0.1766 mL 0.8830 mL 1.7661 mL 4.4152 mL
25 mM 0.1413 mL 0.7064 mL 1.4129 mL 3.5322 mL
30 mM 0.1177 mL 0.5887 mL 1.1774 mL 2.9435 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Risedronic acid
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