S-2474 

S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC₅₀s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.

S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, with IC₅₀s of 11 nM and 27 μM for COX-2 and COX-1^[1]. S-2474 prevents neurons from Aβ-induced cell death significantly in a concentration-dependent manner (IC₅₀ =26±12 nM). S-2474 (10 μM) completely inhibits Aβ(25-35)-induced neuronal cell death. S-2474 also shows neuroprotective effects in the Aβ(1-40)-induced neuronal cell death. S-2474 inhibits the PGD2 generation in a concentration dependent manner (IC₅₀=69.8±21.9 nM). S-2474 (10 μM) lowers the elevated level of PGD2 significantly and reduces radicals from Aβ(25-35)-treated neurons^[2]. S-2474 significantly prevents neurons from undergoing sPLA₂-IIA-induced cell death. S-2474 completely ameliorates sPLA₂-IIA-induced apoptotic features such as the condensation of chromatin and the fragmentation of DNA. Moreover, S-2474 significantly inhibits the sPLA₂-IIA-induced generation of PGD2. S-2474 inhibits sPLA₂-IIA-induced neuronal cell death in a concentration-dependent manner (IC₅₀ = 94 nM)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

365.53

C₂₀H₃₁NO₃S

158089-95-3

OC1=C(C(C)(C)C)C=C(/C=C2CCN(CC)S\2(=O)=O)C=C1C(C)(C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yagami T, et al. Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134(3):673-81.  [Content Brief]

  [2]. Yagami T, et al. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis. Neuropharmacology. 2005 Aug;49(2):174-84. Epub 2005 Apr 1.  [Content Brief]