SNT-207858

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SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC₅₀ of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.

For research use only. We do not sell to patients.

SNT-207858 Chemical Structure

CAS No. : 1104080-42-3

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)^[1]

In Vitro

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice with C26 adenocarcinoma-induced cachexia model^[1]
Dosage:	30 mg/kg
Administration:	Oral administration; once daily; 15 days
Result:	Significantly reduced the tumor induced weight loss.

Molecular Weight

689.54

Formula

C₃₂H₄₅Cl₄N₅O₃

CAS No.

1104080-42-3

SMILES

[H]Cl.O=C(N1CCCC1)N[C@H](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. [Content Brief]

SNT-207858 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNT-2078581104080-42-3SNT207858SNT 207858Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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