2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Satraplatin

Satraplatin  (Synonyms: BMS182751; BMY45594; JM216)

Cat. No.: HY-17576 Purity: 99.79%
SDS COA Handling Instructions

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Satraplatin is an alkylating agent, with potent antitumor effect.

For research use only. We do not sell to patients.

Satraplatin Chemical Structure

Satraplatin Chemical Structure

CAS No. : 129580-63-8

Size Price Stock Quantity
5 mg USD 300 In-stock
10 mg USD 480 In-stock
50 mg USD 1100 In-stock
100 mg USD 1500 In-stock
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500 mg   Get quote  

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Satraplatin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Protocol

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Description

Satraplatin is an alkylating agent, with potent antitumor effect.

In Vitro

Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.
Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC50 of 1.36 ± 0.11 μM[1]. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC50, 7.04 μM), and causes G2/M arrest in KB-R cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Satraplatin Related Antibodies
Clinical Trial
Molecular Weight

500.28

Formula

C10H22Cl2N2O4Pt
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

[Cl-][Pt+4]([O-]C(C)=O)([O-]C(C)=O)([Cl-])([NH3])[NH2]C1CCCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (19.99 mM; ultrasonic and adjust pH to 1 with HCl; DMSO can inactivate Satraplatin's activity)

Ethanol : < 1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

H2O : < 0.1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9989 mL 9.9944 mL 19.9888 mL
5 mM 0.3998 mL 1.9989 mL 3.9978 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

SDS (393 KB)

COA (252 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[1]

Cells are harvested, counted and distributed to microtiter plates in 100 μL medium at a density of 1×104 cells/well. Appropriate dilutions of test compounds (Satraplatin, etc.) are added to a total volume of 200 μL/well and plates incubated under tissue culture conditions for four days. Stock solutions of the compounds are prepared in either 70% ethanol or DMSO and diluted more than 100-fold for the assays. Solvent controls are included in all tests. Dose response curves are obtained by assessing cell proliferation at twofold drug dilutions in triplicate and used for calculation of IC50 values. Cell growth is quantified using a modified tetrazolium dye assay (MTT) and by measurement of the reduced formazane dye at 450 nm wavelength (medium control set to 100% proliferation)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.9989 mL 9.9944 mL 19.9888 mL 49.9720 mL
5 mM 0.3998 mL 1.9989 mL 3.9978 mL 9.9944 mL
10 mM 0.1999 mL 0.9994 mL 1.9989 mL 4.9972 mL
15 mM 0.1333 mL 0.6663 mL 1.3326 mL 3.3315 mL
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Satraplatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Satraplatin129580-63-8BMS182751 BMY45594 JM216BMS 182751BMS-182751BMY45594BMY 45594BMY-45594JM216JM 216JM-216DNA Alkylator/CrosslinkerInhibitorinhibitorinhibit

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