Scyliorhinin II 

Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a K_i of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.

Ki: 2.5 nM (Neurokinin-3 receptor)^[1]

Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a K_i of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with K_i (NK-1 receptor)/K_i (NK-3 receptor) and K_i (NK-2 receptor)/K_i (NK-3 receptor) of 176 and 200^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED₅₀ of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1851.09

C₇₇H₁₁₉N₂₁O₂₆S₃

112748-19-3

Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2

SPSNSKCPDGPDCFVGLM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11.  [Content Brief]

  [2]. Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91.  [Content Brief]