2. Metabolic Enzyme/Protease Autophagy
  3. FXR Autophagy
  4. Sevelamer hydrochloride

Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin.

For research use only. We do not sell to patients.

Sevelamer hydrochloride Chemical Structure

Sevelamer hydrochloride Chemical Structure

CAS No. : 152751-57-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Sevelamer hydrochloride:

Sevelamer hydrochloride Related Antibodies

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  • Purity & Documentation

  • References

  • Customer Review

Description

Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin[1][2][3].

In Vitro

Sevelamer hydrochloride (15 mg/mL; pH=6 or 8) decreases serum levels of gut-derived uremic toxins (such as IAA) or limits the elevation of gut-derived uremic toxins (initial concentration=1 μg/mL or 10 μg/mL)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sevelamer hydrochloride Related Antibodies
In Vivo

Sevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice[3].
Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice[3].
Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

186.08 (monomer)

Formula

(C3H7N.C3H5ClO)x.xHCl
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCC(CC(CC)CNCC(O)CNCC(C)CC(CC)CN)CC.[m].Cl.[m].[c].[b].[a]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Purity & Documentation
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Sevelamer hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sevelamer152751-57-0FXRAutophagyNR1H4polyallylaminehyperphosphatemiachronic kidney diseaseepichlorohydrinInhibitorinhibitorinhibit

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Sevelamer hydrochloride
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HY-13995A
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