2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Linker

Antibody-drug conjugates linker

ADC Linker

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Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

ADC Linker Isoform Specific Products:

ADC Linker Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-151787
    Fmoc-L-Lys(N3-Aca-DIM)-OH
    Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Fmoc-L-Lys(N3-Aca-DIM)-OH
  • HY-156310
    BCN-endo-PEG7-NH2
    BCN-endo-PEG7-NH2 is an ADC Linker containing 7 PEG units. BCN-endo-PEG7-NH2 contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    BCN-endo-PEG7-NH2
  • HY-151849
    Z-L-Dap(N3)-OH
    Z-L-Dap(N3)-OH is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Z-L-Dap(N3)-OH
  • HY-W591336
    Alloc-Val-Ala-PAB-PNP
    Alloc-Val-Ala-PAB-PNP is a cleavable ADC linker.
    Alloc-Val-Ala-PAB-PNP
  • HY-W591286
    Alkyne-Val-Cit-PAB-PNP
    Alkyne-Val-Cit-PAB-PNP is a cleavable ADC linker.
    Alkyne-Val-Cit-PAB-PNP
  • HY-141169A
    (S,E)-TCO2-PEG8-NHS ester
    (S)-TCO-PEG8-NHS ester is an ADC linker containing 8 PEG units. (S)-TCO-PEG8-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
    (S,E)-TCO2-PEG8-NHS ester
  • HY-151747
    Chemical phosphorylation amidite
    Chemical phosphorylation amidite is a click chemical class ADC linker. Click chemistry has good biological orthogonality characteristics: biocompatible, fast and highly specific in the biological environment, and has great application potential in the binding between nucleic acids, lipids, proteins and other molecules.
    Chemical phosphorylation amidite
  • HY-151726
    Azido-PEG(4)-Val-Cit-PAB-PNP
    Azido-PEG(4)-Val-Cit-PAB-PNP is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Azido-PEG(4)-Val-Cit-PAB-PNP
  • HY-151739
    4-Pentynoyl-Val-Ala-PAB
    4-Pentynoyl-Val-Ala-PAB is a click chemical class ADC linker. Click chemistry has good biological orthogonality characteristics: biocompatible, fast and highly specific in the biological environment, and has great application potential in the binding between nucleic acids, lipids, proteins and other molecules.
    4-Pentynoyl-Val-Ala-PAB
  • HY-151785A
    H-L-Dbu(N3)-OH hydrochloride
    H-L-Dbu(N3)-OH is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-L-Dbu(N3)-OH hydrochloride
  • HY-151795
    DACN(Tos) hydrochloride
    DACN(Tos) hydrochloride is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions, such strain-promoted azide-alkyne cycloadditions (SPAAC) by using cycloalkynes. DACNs possesses high thermal and chemical stability along with comparable click reactivity. DACN(Tos) hydrochloride can be used for the research of molecular conjugation.
    DACN(Tos) hydrochloride
  • HY-20560
    (Ac)Phe-Lys(Alloc)-PABC-PNP
    (Ac)Phe-Lys(Alloc)-PABC-PNP is an useful cleavable chemical linker in antibody drug conjugates.
    (Ac)Phe-Lys(Alloc)-PABC-PNP
  • HY-151782A
    H-(Gly)3-Lys(N3)-OH hydrochloride
    		99.79%
    H-(Gly)3-Lys(N3)-OH (hydrochloride) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-(Gly)3-Lys(N3)-OH hydrochloride
  • HY-141152
    Azido-PEG4-Ala-Ala-Asn(Trt)-PAB
    Azido-PEG4-Ala-Ala-Asn(Trt)-PAB is a cleavable ADC linker.
    Azido-PEG4-Ala-Ala-Asn(Trt)-PAB
  • HY-157007
    (S)-TCO-PEG7-NH2
    (S)-TCO-PEG7-NH2 is an ADC linker containing 7 PEG units. (S)-TCO-PEG7-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
    (S)-TCO-PEG7-NH2
  • HY-157006
    (S)-TCO-PEG3-NH2
    (S)-TCO-PEG3-NH2 is an ADC linker containing 3 PEG units. (S)-TCO-PEG3-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
    (S)-TCO-PEG3-NH2
  • HY-151864
    DecarboxyBiotin-Alkyne
    DecarboxyBiotin-Alkyne is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity.
    DecarboxyBiotin-Alkyne
  • HY-151786
    Fmoc-L-Lys(Pentynoyl-DIM)-OH
    Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Fmoc-L-Lys(Pentynoyl-DIM)-OH
  • HY-151843
    N3-L-Lys(Fmoc)-OH
    N3-L-Lys(Fmoc)-OH is a click chemistry reagent containing an azide group. N3-L-Lys(Fmoc)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-L-Lys(Fmoc)-OH
  • HY-151718
    Boc-L-Tyr(PEG(3)-N3)-OH
    Boc-L-Tyr(PEG(3)-N3)-OH is a click chemistry agent containing azide. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Boc-L-Tyr(PEG(3)-N3)-OH
ADC Linker Isoform Comparison

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