2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. APC
  5. APC Inhibitor

APC Inhibitor

APC Inhibitors (10):

Cat. No. Product Name Effect Purity
  • HY-124955
    proTAME
    		Inhibitor 99.94%
    proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase.
  • HY-110287
    Apcin
    		Inhibitor 99.71%
    Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis.
  • HY-116572A
    TASIN-1
    		Inhibitor 99.91%
    TASIN-1 is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC.
  • HY-130841
    Apcin-A
    		Inhibitor ≥98.0%
    Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257).
  • HY-13255
    TAME
    		Inhibitor 99.51%
    TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable.
  • HY-164561
    TASIN-30
    		Inhibitor 98.43%
    TASIN-30 is an EBP inhibitor, with EC50 values of 0.097 μM for EBP competition and 50 μM for DHCR7 competition, respectively.
  • HY-116572
    TASIN-1 hydrochloride
    		Inhibitor
    TASIN-1 hydrochloride is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 hydrochloride represents a potential strategy for prevention and intervention in CRC with mutant APC.
  • HY-W614725
    Apcin-A monohydrochloride
    		Inhibitor
    Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V (HY-130257).
  • HY-P5819
    xStAx-VHLL
    		Inhibitor 99.37%
    xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC–/– mice. xStAx-VHLL can be used as a promising anticancer agent.
  • HY-13255A
    TAME hydrochloride
    		Inhibitor 98.31%
    TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable.