2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Adiponectin Receptor

Adiponectin Receptor

AdipoRs

Adiponectin Receptor

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Adiponectin is a protein which in humans is encoded by the ADIPOQ gene. It is involved in regulating glucose levels as well as fatty acid breakdown. The hormone plays a role in the suppression of the metabolic derangements that may result intype 2 diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease and an independent risk factor for metabolic syndrome. Adiponectin binds to a number of receptors. Two receptors have been identified with homology to G protein-coupled receptors, and one receptor similar to the cadherin family: adiponectin receptor 1 and adiponectin receptor 2.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15848
    AdipoRon
    		Agonist 99.88%
    AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.
    AdipoRon
  • HY-N0166
    Gramine
    		Agonist 99.63%
    Gramine (Donaxine) is a natural alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties.
    Gramine
  • HY-N9182
    Zeaxanthin dipalmitate
    		≥98.0%
    Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (Kd=81.2 nM) and adiponectin receptor 1 (AdipoR1; Kd=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP).
    Zeaxanthin dipalmitate
  • HY-130479
    AdipoR agonist 1
    		Agonist ≥98.0%
    AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research.
    AdipoR agonist 1
  • HY-110164
    AdipoRon hydrochloride
    		Agonist
    AdipoRon hydrochloride is an orally active and specific AdipoR agonist, binding to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM, respectively.
    AdipoRon hydrochloride
  • HY-N0166R
    Gramine (Standard)
    		Agonist
    Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is a natural alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties.
    Gramine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity