2. Signaling Pathways
  3. Neuronal Signaling
  4. Amyloid-β
  5. Amyloid-β Inducer

Amyloid-β Inducer

Amyloid-β Inducers (2):

Cat. No. Product Name Effect Purity
  • HY-136674
    Aftin-5
    		Inducer
    Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively.
  • HY-137370
    2-Hexynyl-5′-N-ethylcarboxamidoadenosine
    		Inducer
    2-Hexynyl-5′-N-ethylcarboxamidoadenosine (HENECA) is a selective A2A adenosine receptor agonist. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine increases intracellular cAMP level, and inhibits TNFα-evoked MMP-3 release. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine induces Aβ42 production in SH-SY5Y cells.