CCR2 Antagonist

CCR2 Antagonists (25):

Cat. No.	Product Name	Effect	Purity

HY-15418

RS 504393	Antagonist	99.43%
RS 504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).

HY-50674

INCB3344	Antagonist	99.73%
INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC₅₀ values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.

HY-13406

TAK-779	Antagonist	99.73%
TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a K_i of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC₅₀ and EC₉₀ of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.

HY-18611

RS102895 hydrochloride	Antagonist	99.87%
RS102895 hydrochloride is a potent CCR2 antagonist, with an IC₅₀ of 360 nM, and shows no effect on CCR1.

HY-14882

Cenicriviroc	Antagonist	99.01%
Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.

HY-108432

BMS-741672	Antagonist
BMS-741672 is a selective and orally active CCR2 antagonist with an IC₅₀ of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5.

HY-13245

PF-4136309	Antagonist	99.79%
PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC₅₀s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

HY-18611A

RS102895	Antagonist	99.97%
RS102895 is a potent CCR2 antagonist, with an IC₅₀ of 360 nM, and shows no effect on CCR1.

HY-14882A

Cenicriviroc Mesylate	Antagonist	99.04%
Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.

HY-109593

BMS-813160	Antagonist	99.93%
BMS-813160 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC₅₀s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation.

HY-103362

CCR2 antagonist 4 hydrochloride	Antagonist	99.86%
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM.

HY-50669A

MK-0812 Succinate	Antagonist	99.90%
MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.

HY-50081

CCR2-RA-[R]	Antagonist	99.71%
CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC₅₀ of 103 nM.

HY-101908

BMS CCR2 22	Antagonist	99.87%
BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC₅₀ of 5.1 nM) and potent functional antagonism (calcium flux IC₅₀ of 18 nM and chemotaxis IC₅₀ of 1 nM).

HY-15450A

INCB 3284	Antagonist	99.30%
INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC₅₀ of 3.7 nM. INCB 3284 can be used in the research of acute liver failure.

HY-112792

CCR2 antagonist 1	Antagonist	98.00%
CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a K_i of 2.4 nM.

HY-108323

CCR2 antagonist 4	Antagonist	99.89%
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM.

HY-135891

AZD2423	Antagonist	99.91%
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC₅₀ of 1.2 nM for CCR2 Ca²⁺ flux .

HY-103355

YM022	Antagonist	99.93%
YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the K_i values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo.

HY-50669

MK-0812	Antagonist	99.75%
MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2.

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