2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK8 Isoform
  6. CDK8 Degrader

CDK8 Degrader

CDK8 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-149209
    LL-K8-22
    		Degrader 99.76%
    LL-K8-22 is a potent, selective and durable CDK8-cyclin C dual degrader, with DC50 values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven carcinogenic transcriptional programs. LL-K8-22 can be used for triplenegative breast cancer (TNBC) research.