2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX
  5. COX Inhibitor

COX Inhibitor

COX Isoform Comparison

COX Inhibitors (809):

Cat. No. Product Name Effect Purity
  • HY-167630
    Ketoprofen sodium
    		Inhibitor
    Ketoprofen (RP-19583) sodium is a non-steroidal anti-inflammatory agent. Ketoprofen sodium can inhibit the activity of Cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). Ketoprofen is potential in the research of inflammation, immunology, and metabolic disease such as obesity.
  • HY-B0335S
    Tolfenamic acid-d4
    		Inhibitor
    Tolfenamic acid-d4 is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].
  • HY-76251S1
    (rac)-Etodolac-d3
    		Inhibitor
    (rac)-Etodolac-d3 is a labelled racemic Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)
  • HY-B0574S1
    Mefenamic Acid-d3
    		Inhibitor
    Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
  • HY-U00275
    COX-2-IN-1
    		Inhibitor
    COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM.
  • HY-101655
    COX-2-IN-2
    		Inhibitor 99.53%
    COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
  • HY-U00197
    Tilmacoxib
    		Inhibitor ≥99.0%
    Tilmacoxib (JTE522) is a highly selective, time-dependent and irreversible human COX-2 inhibitor with an IC50 of 85 nM in an enzyme assay.
  • HY-U00347
    COX/5-LO-IN-1
    		Inhibitor
    COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.
  • HY-U00239
    SC58451
    		Inhibitor
    SC58451 is a potent and selective Cox-2 inhibitor.