Caspase Inhibitor

Caspase Inhibitors (127):

Cat. No.	Product Name	Effect	Purity

HY-RS01956

Casp4 Mouse Pre-designed siRNA Set A	Inhibitor
Casp4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Casp4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-P10243

Ac-VAD-CMK	Inhibitor
Ac-VAD-CMK is a pan inhibitor for caspase 1.

HY-RS01963

Casp7 Mouse Pre-designed siRNA Set A	Inhibitor
Casp7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Casp7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-P5956

Ac-AAVALLPAVLLALLAP-LEHD-CHO	Inhibitor
Ac-AAVALLPAVLLALLAP-LEHD-CHO is an inhibitor of caspases 4, 5 and 9. Ac-AAVALLPAVLLALLAP-LEHD-CHO shows protective effects upon Neocarzinostatin (HY-111183)-treated MCF-7 cells.

HY-19696S1

Tauroursodeoxycholate-d₄	Inhibitor
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-B1138S

Fenbufen-d₉	Inhibitor
Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-RS01951

Casp2 Rat Pre-designed siRNA Set A	Inhibitor
Casp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Casp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-W011254

Ac-VAD-CHO	Inhibitor
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells.

HY-RS01950

Casp2 Mouse Pre-designed siRNA Set A	Inhibitor
Casp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Casp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-N0361S

Dihydrocapsaicin-d₃	Inhibitor
Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361). Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat.

HY-RS01955

CASP4 Human Pre-designed siRNA Set A	Inhibitor
CASP4 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-P10241

Ac-LEHD-CHO	Inhibitor
Ac-LEHD-CHO is an inhibitor for caspase 8/9. Ac-LEHD-CHO prevents GalN/TNF-α-induced hepatotoxicity and hepatocyte apoptosis.

HY-19696S2

Tauroursodeoxycholate-d₄-1	Inhibitor
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-P1094

AZ-10417808	Inhibitor
AZ-10417808 is a selective caspase-3 inhibitor. AZ-10417808 blocks apoptosis signaling pathway by inhibiting caspase-3 activity. AZ-10417808 can be used to study the effect of nicotine on plasmacytoid dendritic cell migration.

HY-RS01962

CASP7 Human Pre-designed siRNA Set A	Inhibitor
CASP7 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-155402

Antiproliferative agent-42	Inhibitor
Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC₅₀ value of 12.54 μM.

HY-N0265R

Asperosaponin VI (Standard)	Inhibitor
Asperosaponin VI (Standard) is the analytical standard of Asperosaponin VI. This product is intended for research and analytical applications. Asperosaponin VI is a saponin component from Dipsacus asper. Asperosaponin VI induces osteoblast differentiation through the BMP-2/p38 and ERK1/2 signaling pathways. Asperosaponin VI protects against hypoxia-induced cardiomyocyte apoptosis by activating the PI3K/Akt and CREB pathways. Additionally, Asperosaponin VI also has antidepressant and wound-healing-promoting activities.

HY-P6440

Met-12	Inhibitor
Met-12 is a small peptide inhibitor of the Fas receptor. Met-12 can inhibit Fas receptor-mediated photoreceptor cell apoptosis, reduce Caspase activation. Met-12 can be used in the research of photoreceptor.

HY-14584A

PQ-1 succinate	Inhibitor
PQ-1 succinate is an inhibitor for gap junction, which suppresses the gap junction dye transfer activity in retinal neurosensory R28 cells, and inhibits the CoCl₂-induced ischemic apoptosis in retinal cell.

HY-16658C

Z-VA-DL-D-FMK	Inhibitor
Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) is an inhibitor for caspase. Z-VA-DL-D-FMK binds irreversibly to caspases, increases the sensitivity of TNF-α, and activates HIV replication in infected T cell ACH-2.

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