2. Signaling Pathways
  3. Epigenetics
  4. DNA Methyltransferase
  5. MGMT Isoform
  6. MGMT Inhibitor

MGMT Inhibitor

MGMT Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-13668
    Lomeguatrib
    		Inhibitor 99.77%
    Lomeguatrib is a O6-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC50s of 9 nM in cell-free assay and ～6?nM in MCF-7 cells.
  • HY-13057
    O6BTG-octylglucoside
    		Inhibitor
    O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.
  • HY-175299
    Hedgehog IN-11
    		Inhibitor
    Hedgehog IN-11 is an orally active Hedgehog inhibitor. Hedgehog IN-11 downregulates the expression of O6-methylguanine-DNA methyltransferase (MGMT) to impair the Temozolomide (TMZ) (HY-17364) resistance by inhibiting the Hedgehog pathway. Hedgehog IN-11 shows improved inhibition of cell migration and invasion, and induced cell apoptosis in TMZ-resistant GBM cell lines. Hedgehog IN-11 is predicted by computer simulation to have good blood-brain barrier penetration. Hedgehog IN-11 can be used for the study of glioblastoma (GBM).