2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. G-quadruplex
  5. G-quadruplex Inducer

G-quadruplex Inducer

G-quadruplex Inducers (2):

Cat. No. Product Name Effect Purity
  • HY-15176A
    Pyridostatin hydrochloride
    		Inducer 98.53%
    Pyridostatin (RR82) hydrochloride is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin hydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin hydrochloride targets the proto-oncogene Src. Pyridostatin hydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.
  • HY-151263
    G4/HDAC-IN-1
    		Inducer
    G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer.