2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. GPR139
  5. GPR139 Agonist

GPR139 Agonist

GPR139 Agonists (4):

Cat. No. Product Name Effect Purity
  • HY-19838
    JNJ-63533054
    		Agonist 99.90%
    JNJ-63533054 is a potent, selective and orally active GPR139 agonist with an EC50 of 16 nM for human GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ-63533054 can cross the blood-brain barrier (BBB).
  • HY-132228
    Zelatriazin
    		Agonist 99.89%
    Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia.
  • HY-101777
    TC-O 9311
    		Agonist 99.70%
    TC-O 9311 is a potent orphan G protein-coupled receptor 139 (GPR139) agonist with an EC50 of 39 nM.
  • HY-149651
    GPR139 agonist-2
    		Agonist 99.80%
    GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research.